The predictive value of CRP, CEA, IL-6, IL-8, and TNF? in the diagnosis of malignant pleural effusions

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dc.contributor.authorSen H.S.
dc.contributor.authorAbakay O.
dc.contributor.authorDalli A.
dc.contributor.authorSezgi C.
dc.contributor.authorAbakay A.
dc.contributor.authorCoskunsel M.
dc.date.accessioned2024-04-24T18:45:50Z
dc.date.available2024-04-24T18:45:50Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: In this study, we investigated the potential utility of some simple, rapid, biochemical tests that detect the tumor markers interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor alpha (TNF?), C reactive protein (CRP), and carcinoembryonic antigen (CEA) in diagnosing malignant pleural effusions (MPEs) in exudative pleural fluids. Material and Methods: The study included 70 patients who had exudative PEs. The presence of CRP, CEA, IL-6, IL-8, and TNF? were investigated in the patients' pleural fluids. The cases were grouped into a malignant pleural effusion (PE) group (n = 27) and a benign PE group (n = 43) according to their etiological diagnosis, and the median levels of CRP, CEA, IL-6, IL-8, and TNF? in the two groups were compared. Results: The levels of pleural fluid CEA and IL-6 were significantly higher in the malignant PE group compared with the benign PE group (p <0.01 and p = 0.002, respectively). A meaningful difference was not found between the median value of the pleural fluid CRP IL-8 and TNF? levels in the two groups (p >0.05). We used Roc curve analysis to determine the sensitivity and specificity of CEA as a marker of malignant pleural effusion. When the CEA cut-off point was 1 ng/ml, the sensitivity was found to be 85%, and the specificity was found to be 51%. When the CEA cutoff point was 17 ng/ml, the sensitivity was 29%, and the specificity was 97%. Conclusion: Although the number of cases in the study is low, our findings suggested that CEA and IL-6 may be useful in distinguishing whether exudative PEs are malignant or benign.en_US
dc.identifier.endpage1617en_US
dc.identifier.issn1840-2291
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84863192766
dc.identifier.scopusqualityN/A
dc.identifier.startpage1611en_US
dc.identifier.urihttps://hdl.handle.net/11468/24910
dc.identifier.volume6en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofHealthMED
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCeaen_US
dc.subjectIl-6en_US
dc.subjectMalignant Pleural Effusionen_US
dc.titleThe predictive value of CRP, CEA, IL-6, IL-8, and TNF? in the diagnosis of malignant pleural effusionsen_US
dc.titleThe predictive value of CRP, CEA, IL-6, IL-8, and TNF? in the diagnosis of malignant pleural effusions
dc.typeArticleen_US

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