The relationship of oxidative metabolism to treatment response in major depression: A biological basis for treatment duration

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dc.contributor.authorSelek, Salih
dc.contributor.authorDalkılıç, Alican
dc.contributor.authorKaya, Mehmet Cemal
dc.contributor.authorSavaş, Haluk Asuman
dc.contributor.authorBez, Yasin
dc.contributor.authorÇelik, Hakim
dc.contributor.authorErel, Özcan
dc.contributor.orcid0000-0001-5197-5682
dc.contributor.orcid0000-0002-2996-3236
dc.contributor.orcid0000-0003-4357-8809
dc.date.accessioned2024-04-24T17:56:10Z
dc.date.available2024-04-24T17:56:10Z
dc.date.issued2012
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground: We aimed to determine the relationship between antidepressant treatment and oxidative metabolism in patients with major depression. Materials and methods: Two groups, the patients diagnosed with depression (N = 21), and healthy controls (N = 40), were enrolled in the study. The patients received naturalistic antidepressant treatment. Serum samples were collected prior to treatment and at the end of the 8 weeks of antidepressant treatment. Those participants in the control group were sampled only once. The total antioxidant status (TAS) and total oxidant status (TOS) were measured and oxidative stress index (OSI) was calculated. Severity of depression in patients was also measured both prior to and after 8 weeks of antidepressant treatment. Results: In terms of TAS, TOS, and OSI there were significant differences between the groups both at the baseline. Baseline and final HAM-D scores of the patient group differed significantly. The baseline TAS, TOS, and OSI levels of patients did not change significantly after antidepressant treatment. The duration of illness was not correlated with baseline serum levels of TAS, TOS, and OSI. Patients who were deemed to be unresponsive to the antidepressant treatment differed significantly from the controls both at the baseline and at the final visit for TAS, TOS, and OSI. Additionally, treatment responsive patients did not show any similar difference in terms of TOS and OSI levels. Discussion: Chronic increase in anti-oxidant and oxidant levels in patients with major depression may be related to the elevation of anti-oxidant defenses that were developed in response to increased oxidative metabolism.en_US
dc.identifier.citationSelek, S., Dalkılıç, A., Kaya, M. C., Savaş, H. A., Bez, Y., Çelik, H. ve diğerleri. (2012). The relationship of oxidative metabolism to treatment response in major depression: A biological basis for treatment duration. Neurology Psychiatry and Brain Research, 18(1), 15-18.
dc.identifier.doi10.1016/j.npbr.2011.11.001
dc.identifier.endpage18en_US
dc.identifier.issn0941-9500
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84855826969
dc.identifier.scopusqualityQ3
dc.identifier.startpage15en_US
dc.identifier.urihttps://doi.org/10.1016/j.npbr.2011.11.001
dc.identifier.urihttps://hdl.handle.net/11468/23338
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0941950011000406?via%3Dihub
dc.identifier.volume18en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofNeurology Psychiatry and Brain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Depressantsen_US
dc.subjectDepressionen_US
dc.subjectFree radicalsen_US
dc.subjectMajor depressive disorderen_US
dc.subjectNeurobiologyen_US
dc.subjectOxidative stressen_US
dc.subjectTotal oxidative statusen_US
dc.titleThe relationship of oxidative metabolism to treatment response in major depression: A biological basis for treatment durationen_US
dc.titleThe relationship of oxidative metabolism to treatment response in major depression: A biological basis for treatment duration
dc.typeArticleen_US

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