Investigation of the Sox-9 and Caspase-6 Immune Activity in Placentas of Pregnant Women with GDM

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dc.contributor.authorÖcal, Ece
dc.contributor.authorAkalin, Senem
dc.contributor.authorDeveci, Engin
dc.date.accessioned2025-02-22T14:13:31Z
dc.date.available2025-02-22T14:13:31Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: In this study, we investigated the immunohistochemical staining of Sox-9 and Caspase-6 expression in placentas of pregnant woman with gestational diabetes mellitus (GDM). Material and Methods: Placentas of 20 healthy and 20 women with GDM were processed for routine histological tissue processing. The biochemical and clinical parameters of patients were recorded. Placentas were stained with hematoxylin-eosin and Sox-9 and Caspase-6 immunostaining. Results: In control group, Sox-9 expression was negative in decidual and connective cells and endothelial cells. In GDM group, Sox-9 expression was increased especially in the decidual cells. For the Caspase-6 expression, Caspase-6 reaction was mainly in maternal region in control group. In GDM group, Caspase-6 reaction was increased in decidual cells, in endothelial cells and in the syncytial nodes. Conclusion: Expression of Sox-9 transformed the decidua cells and lead to apoptotic pathway via Caspase-6 expression.en_US
dc.identifier.doi10.37990/medr.1252256
dc.identifier.endpage448en_US
dc.identifier.issn2687-4555
dc.identifier.issue3en_US
dc.identifier.startpage445en_US
dc.identifier.trdizinid1263417en_US
dc.identifier.urihttps://doi.org/10.37990/medr.1252256
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1263417
dc.identifier.urihttps://hdl.handle.net/11468/30038
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofMedical records-international medical journal (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_TR_20250222
dc.subjectGDMen_US
dc.subjectplacentaen_US
dc.subjectSox-9en_US
dc.subjectcaspase-6en_US
dc.titleInvestigation of the Sox-9 and Caspase-6 Immune Activity in Placentas of Pregnant Women with GDMen_US
dc.typeArticleen_US

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