Effect of gallic acid on liver injury during obstructive cholestasis after bile duct ligation in rat

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dc.contributor.authorEkinci, Aysın
dc.contributor.authorOkur, Mehmet Hanifi
dc.contributor.authorBasuguy, Erol
dc.contributor.authorArslan, Aziz Serkan
dc.contributor.authorAydoğdu, Gülay
dc.contributor.authorZeytun, Hikmet
dc.date.accessioned2024-04-24T19:13:05Z
dc.date.available2024-04-24T19:13:05Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: To investigate the hepatoprotective, anti-inflammatory and antioxidant effects of gallic acid (GA) against obstructive cholestasis (OC) -induced liver damage in rats. Methods: Thirty female Sprague-Dawley rats were divided into three groups. Group 1 (n=10) was the sham-operated group. In group 2 and group 3, hepatoduodenal ligament dissection was performed after laparotomy. Once the common bile duct was made apparent, it was ligated with 4/0 silk surgical suture and cut between both sutures. Group 2 (n=10) was the control group. Group 3 (n=10) was the GA group. GA (50 mg/kg) was administered by oral gavage daily for 10 days. At the end of the experiment on day 10, the rats were anesthetized. Fibrosis, inflammation, ductal proliferation and necrosis were evaluated histopathologically. Serum levels of AST, ALT, TBIL, DBIL, LDH and GGT levels were determined. In the serum and liver, TAS, TOS, MDA, TNF-?, IL-1, IL-6, and IL 10 levels were evaluated.Results: When group 2 and group 3 were compared histopathologically, fibrosis and inflammation were significantly lower in group 3. In group 3, all LFTs (except DBIL), liver and serum IL-6, IL-1, TOS, MDA, and TNF-? levels were significantly lower than group 2, whereas IL-10 and TAS values were increased. Conclusion: Findings of this research indicate that GA may be effective against OC-induced liver damage in a rat model. We presume that the beneficial effects of GA are closely associated with its antioxidant and anti-inflammatory activities. Therefore, we think that using GAcan save us time before resorting to the surgical method.en_US
dc.identifier.doi10.30714/j-ebr.2021165781
dc.identifier.endpage57en_US
dc.identifier.issn2618-6454
dc.identifier.issue1en_US
dc.identifier.startpage47en_US
dc.identifier.trdizinid417910
dc.identifier.urihttps://doi.org/10.30714/j-ebr.2021165781
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/417910
dc.identifier.urihttps://hdl.handle.net/11468/28340
dc.identifier.volume4en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofExperimental Biomedical Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffect of gallic acid on liver injury during obstructive cholestasis after bile duct ligation in raten_US
dc.titleEffect of gallic acid on liver injury during obstructive cholestasis after bile duct ligation in rat
dc.typeArticleen_US

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