The increasing use of intravesical therapies for stage T1 bladder cancer coincides with decreasing survival after cystectomy

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dc.contributor.authorSahin, Hayrettin
dc.date.accessioned2024-04-24T17:40:32Z
dc.date.available2024-04-24T17:40:32Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: In this retrospective study, it is examined the patterns of use of intravesical therapy (IVT) in high-grade T1 bladder cancer and the subsequent impact on survival for patients ultimately proceeding to radical cystectomy ( RC). Patients and Methods: The study evaluates a total of 104 patients with T1 high-grade transitional cell carcinoma (TCC) and who underwent RC between 1990 and 2005. Patients were divided into two groups; those having RC before 1998 and those after 1998. Trends in time from diagnosis to RC, courses of IVT, recurrence and pathological stage were analysed using two-sample t-tests with 95% confidence intervals. Results: Before 1998, 28 of 38 patients (74%) proceeded directly to RC with no IVT, vs 20 of 47 (43%) after 1998 (P=0.004). The mean number of IVT courses per patient was 0.53 before 1998 and 1.2 afterward (P=0.016). Patients who had RC before 1998 had a 69.7% disease-free survival at 5 years, vs 39.6% for those after 1998 (P=0.05). Conclusion: This retrospective study indicates that patients having RC for T1 high-grade TCC after 1998 were more likely to receive IVT. These same patients had a worsening diseasefreesurvival. The decreasing in survival might be related to an increased use of IVT. The possibility that IVT might be delaying curative surgery.en_US
dc.identifier.endpage29en_US
dc.identifier.issn2147-2270
dc.identifier.issue2en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://hdl.handle.net/11468/21844
dc.identifier.volume6en_US
dc.identifier.wosWOS:000219334400006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isotren_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofUroonkoloji Bulteni-Bulletin of Urooncology
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe increasing use of intravesical therapies for stage T1 bladder cancer coincides with decreasing survival after cystectomyen_US
dc.titleThe increasing use of intravesical therapies for stage T1 bladder cancer coincides with decreasing survival after cystectomy
dc.typeEditorialen_US

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