The effect of alpha-lipoic acid on nerve tissue healing after sciatic nerve crush injury in rats

Basit Öğe Kaydı
dc.authorid0000-0002-0826-5965en_US
dc.authorid0000-0001-8826-4139en_US
dc.authorid0000-0002-4614-5235en_US
dc.authorid0000-0001-5786-9063en_US
dc.authorid0000-0001-9042-8542en_US
dc.authorid0000-0001-5554-2585en_US
dc.authorid0000-0002-4260-9821en_US
dc.contributor.authorYücel, Murat
dc.contributor.authorAktaş, Özgür Yusuf
dc.contributor.authorZengi, Oğuzhan
dc.contributor.authorTaş, Abdurrahim
dc.contributor.authorTufan, Azmi
dc.contributor.authorEren, Burak
dc.contributor.authorGuzey, Feyza Karagöz
dc.date.accessioned2023-08-03T12:12:47Z
dc.date.available2023-08-03T12:12:47Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalıen_US
dc.description.abstractAim: Crush injury damages the nerve, affects its function and causes oxidative stress. Alpha-lipoic acid (ALA) is an antioxidant agent with protective effects on the nerve tissue. In this study, we aimed to investigate the effects of ALA in the treatment of crush sciatic nerve injury in rats. Materials and Methods: Forty rats were divided into five groups. Walking Track Analysis (WTA) was performed in all groups before sacrificing the sciatic nerve. In group I (sham group), the sciatic nerve was exposed but not crushed, whereas in group II (early control group, 24th hour), group III (late control group, 7th day), group IV (early exper imental group, 24th hour), and group V (late control group, 7th day), the sciatic nerve was exposed and clipped with an aneurysm clip for 300 seconds. One hour after the crush injury, subjects in groups II and III were given saline (2.5 ml, intraperitoneally), while ALA (100 mg/kg, intraperitoneally) was administered in Groups IV and V. WTA was per formed in Groups I, II, and IV at the 24th hour after clipping and was performed in Groups III and V at 7th day after clipping. In all groups, the Sciatic Functional Index (SFI) was calculated after WTA. Following the completion of WTA, sciatic nerve tissue samples were obtained for the measurement of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) enzyme values. Results: The SFI scores in groups II, III, IV, and V were significantly lower than that of sham group (p<0.05), while no significant difference was found between groups II and IV and between groups III and V (p>0.05). The CAT values of groups II and IV, the GSH-Px value and MDA value of group IV, and the SOD values of groups II and IV were found to be significantly higher than those of sham group (p<0.05). However, no significant difference was found among groups I, III, and V with regard to CAT, GSH-Px, MDA and SOD values (p>0.05). Conclusion: The results indicated that a single dose of ALA (100 mg/kg) administered intraperitoneally one hour after the sciatic nerve crush injury had no therapeutic efficacy at 24 hours and 7 days after the administration. Further experimental studies are needed to evaluate the effectiveness of ALA applied in several doses rather than a single dose in crush peripheral nerve injury models.en_US
dc.identifier.citationYücel, M., Aktaş, Ö. Y., Zengi, O., Taş, A., Tufan, A., Eren, B. ve diğerleri. (2023). The effect of alpha-lipoic acid on nerve tissue healing after sciatic nerve crush injury in rats. Annals of Medical Research, 30(4), 684-691.en_US
dc.identifier.doi10.5455/annalsmedres.2023.02.061
dc.identifier.endpage691en_US
dc.identifier.issn2636-7688
dc.identifier.issue6en_US
dc.identifier.startpage684en_US
dc.identifier.trdizinid1189115
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1189115
dc.identifier.urihttps://hdl.handle.net/11468/12417
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1189115
dc.identifier.volume30en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorTaş, Abdurrahim
dc.language.isoenen_US
dc.publisherTurgut Ozal Medical Centeren_US
dc.relation.ispartofAnnals of Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlpha-lipoic aciden_US
dc.subjectCrush injuryen_US
dc.subjectPeripheral nerveen_US
dc.subjectRaten_US
dc.subjectThe sciatic nerveen_US
dc.titleThe effect of alpha-lipoic acid on nerve tissue healing after sciatic nerve crush injury in ratsen_US
dc.titleThe effect of alpha-lipoic acid on nerve tissue healing after sciatic nerve crush injury in rats
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
The effect of alpha-lipoic acid on nerve tissue healing after sciatic nerve crush injury in rats.pdf
Boyut:
581.59 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Cerrahi Tıp Bilimleri Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu