Investigation of the Sox-9 and Caspase-6 Immune Activity in Placentas of Pregnant Women with GDM

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dc.contributor.authorÖcal, Ece
dc.contributor.authorAkalın, Senem Alkan
dc.contributor.authorDeveci, Engin
dc.date.accessioned2025-03-08T18:29:12Z
dc.date.available2025-03-08T18:29:12Z
dc.date.issued2023
dc.departmentDicle Üniversitesi
dc.description.abstractAim: In this study, we investigated the immunohistochemical staining of Sox-9 and Caspase-6 expression in placentas of pregnant woman with gestational diabetes mellitus (GDM). Material and Methods: Placentas of 20 healthy and 20 women with GDM were processed for routine histological tissue processing. The biochemical and clinical parameters of patients were recorded. Placentas were stained with hematoxylin-eosin and Sox-9 and Caspase-6 immunostaining. Results: In control group, Sox-9 expression was negative in decidual and connective cells and endothelial cells. In GDM group, Sox-9 expression was increased especially in the decidual cells. For the Caspase-6 expression, Caspase-6 reaction was mainly in maternal region in control group. In GDM group, Caspase-6 reaction was increased in decidual cells, in endothelial cells and in the syncytial nodes. Conclusion: Expression of Sox-9 transformed the decidua cells and lead to apoptotic pathway via Caspase-6 expression.
dc.identifier.doi10.37990/medr.1252256
dc.identifier.endpage8
dc.identifier.issn2687-4555
dc.identifier.issue3
dc.identifier.startpage445
dc.identifier.urihttps://doi.org/10.37990/medr.1252256
dc.identifier.urihttps://hdl.handle.net/11468/31719
dc.identifier.volume5
dc.language.isoen
dc.publisherTıbbi Kayıtlar Derneği
dc.relation.ispartofMedical Records
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_21250205
dc.subjectSox-9
dc.subjectcaspase-6
dc.subjectGDM
dc.subjectplacenta
dc.subjectSox-9
dc.subjectcaspase-6
dc.subjectGDM
dc.subjectplacenta
dc.titleInvestigation of the Sox-9 and Caspase-6 Immune Activity in Placentas of Pregnant Women with GDM
dc.typeArticle

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