Effects of Sublethal Doses of Thiacloprid, a Neonicotinoid Insecticide, on Learning and Memory Performance of Mice

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dc.contributor.authorAkkoc, Hasan
dc.contributor.authorAcar, Abdullah
dc.contributor.authorToprak, Gulten
dc.contributor.authorUyar, Emre
dc.date.accessioned2024-04-24T17:21:14Z
dc.date.available2024-04-24T17:21:14Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Objective: Thiacloprid (THI), a neonicotinoid insecticide, currently one of the most preferred insecticides worldwide. Although they are claimed to be less hazardous on mammals, late studies revealed the harmful effects of this kind of insecticides. However, there are few studies examining the effect of THI on learning and memory performance in the literature. This study was conducted to investigate the effects of sublethal doses of THI on learning and memory functions and to determine the effect of the protocol on biochemical parameters. Materials and Methods: In this outcome, 50, 100 and 200 mg kg(-1) THI were administered by oral gavage for 3 weeks in mice (n:7). At the end of this process, a novel object recognition (NOR) and passive avoidance (PA) tests were conducted to measure learning and memory functions. Brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) levels were measured biochemically. Results: In the NOR test, reductions in the discrimination index values were observed with THI applications. The step-through latencies of the mice to enter the dark compartment in the retention trial of the PA test was reduced similarly in THI applied groups. The biochemical investigations revealed that BDNF and GPx levels in the brain tissue were significantly reduced in all groups compared to the control group, while a significant reduction in NGF levels was observed only in 200 mg kg(-1) applied group. There was no significant difference in SOD and CAT levels between test groups. Conclusion: These results indicated that sublethal, chronic THI application degenerates the learning and memory functions with affecting BDNF, NGF and GPx levels.en_US
dc.identifier.doi10.3923/ijp.2020.72.78
dc.identifier.endpage78en_US
dc.identifier.issn1811-7775
dc.identifier.issn1812-5700
dc.identifier.issue1en_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://doi.org/10.3923/ijp.2020.72.78
dc.identifier.urihttps://hdl.handle.net/11468/19413
dc.identifier.volume16en_US
dc.identifier.wosWOS:000507632400009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherAsian Network Scientific Information-Ansineten_US
dc.relation.ispartofInternational Journal of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThiaclopriden_US
dc.subjectNeonicotinoid Insecticideen_US
dc.subjectLearning-Memory Performanceen_US
dc.subjectNovel Object Recognition Testen_US
dc.subjectBrain-Derived Neurotrophic Factor (Bdnf)en_US
dc.subjectGlutathione Peroxidase (Gpx)en_US
dc.titleEffects of Sublethal Doses of Thiacloprid, a Neonicotinoid Insecticide, on Learning and Memory Performance of Miceen_US
dc.titleEffects of Sublethal Doses of Thiacloprid, a Neonicotinoid Insecticide, on Learning and Memory Performance of Mice
dc.typeArticleen_US

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