The role of L-Arginine, a nitric oxide precursor, on deteriorating cardio-respiratory effects in experimentally produced traumatic diaphragmatic injury

Basit Öğe Kaydı
dc.contributor.authorÖztürk H.
dc.contributor.authorGezici A.
dc.contributor.authorOtçu S.
dc.contributor.authorDokucu A.I.
dc.contributor.authorKaya S.
dc.contributor.authorKirbaş G.
dc.contributor.authorYücesan S.
dc.date.accessioned2024-04-24T17:58:42Z
dc.date.available2024-04-24T17:58:42Z
dc.date.issued2002
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: In this study we aimed to in vestigate the protective effects of L-Arginine on cardio-respiratory complications in a diaphragmatig rupture model. Method: 40 Sprague-Dawley rats were used in this study. In Group I, only thoracotomy was performed. In Group II, III and IV, following left thoracotomy, the stomach was pulled into thorax and the intraabdominal pressure was increased by an insufflator. L-Arginine (L-Arg) was given in GIII and L-NAME was given in GIV at the 45th minute of the study, The parameters such as arterial blood pressure (BP), heart rate (HR), arterial blood gases analysis (pO2, pCO2, pH) and pulmonary scintigraphy were measured at the baseline, 30th, 45th and 60th minutes of the study. The left lungs were extracted for histopathological examination. Results: In the values of blood gases analysis following the performing herniation model the pO2 and pH values decreased and pCO2 values increased in GII in comparison with GI. The mean values of blood gases analysis in GIII following L-Arg infusion at the 60th minute of the study were found to be increased for pO2 and pH values and to be decreased for pCO2 values in comparison with the values of GII. Following L-NAME administration to the GIV, there was no difference found between GII and GIV. Pulmonary uptake decreased in GII, GIII and GIV when compared with GI, whereas pulmonary uptake in GIII was significantly increased in comparison with GII and GIV. Conclusion: The use of the precursor of nitric oxide, L-Arginine, may provide protective effects on cardio-respiratory complications related to organ herniation in the acute period of traumatic diaphragmatic rupture.en_US
dc.identifier.endpage21en_US
dc.identifier.issn1016-5142
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-17044447559en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage16en_US
dc.identifier.urihttps://hdl.handle.net/11468/24066
dc.identifier.volume16en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.relation.ispartofPediatrik Cerrahi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiaphragmen_US
dc.subjectHerniaen_US
dc.subjectNitric Oxideen_US
dc.subjectRuptureen_US
dc.subjectTraumaen_US
dc.titleThe role of L-Arginine, a nitric oxide precursor, on deteriorating cardio-respiratory effects in experimentally produced traumatic diaphragmatic injuryen_US
dc.title.alternativeDeneysel travmatik diyafragma rüptürü sonrasi gelişen kardiyo-respiratuvar etkileri üzerine nitrik oksit prekürsörü L-Arginin'in etkisien_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu