Changes in the Bladder After Spinal Cord Injury and Expression of VEGF and APAF-1

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dc.contributor.authorYamis, Mehmet
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:47:35Z
dc.date.available2024-04-24T17:47:35Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: A spinal cord injury (SCI) is damage to the spinal cord either from trauma, loss of its normal blood supply, or compression from tumor or infection. In this study we focused on alterations in the bladder tissue with angiogenic and apoptotic aspects after spinal cord injury. STUDY DESIGN: Twenty Wistar Albino rats were categorized as control and SCI groups. At T7-T9 vertebras, a steel rod was dropped from 10 cm to create a spinal cord injury under anesthesia. Rats were decapitated and spinal tissue was processed to measure malondialdehyde (MDA), glutathione (GSH), and myeloperoxidase (MPO). RESULTS: MDA, MPO, epithelial degeneration, vascular dilation, inflammation, VEGF, and APAF-1 expressions in the SCI group were statistically higher than those in the control group. GSH content of the SCI group was statistically lower than that in the control group. In the hematoxylin-eosin-stained sections of the control group, normal histology was observed in bladder tissue. In the SCI group, degeneration epithelial cells, thinned epithelium, increased fibrosis, dilated and congested blood vessels, and hyperplastic endothelial cells were observed. In the control group, VEGF expression was slightly observed in some epithelial cells and vascular cells. In the SCI group, VEGF expression was increased in inflammatory and vascular endothelial cells. For APAF-1 expression, the control group showed no expression. In the SCI group, APAF-1 expression was positive in degenerated epithelial cells and connective tissue cells. CONCLUSION: It is thought that the urination reflex was affected due to increased inflammation in the bladder tissue, leading to alterations in the regulation and function of the muscles.en_US
dc.identifier.endpage142en_US
dc.identifier.issn0884-6812
dc.identifier.issue3en_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://hdl.handle.net/11468/22621
dc.identifier.volume43en_US
dc.identifier.wosWOS:000691771000005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApaf-1en_US
dc.subjectBladderen_US
dc.subjectSpinal Cord Injuryen_US
dc.subjectUrinary Bladderen_US
dc.subjectVegfen_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.subjectWistar Ratsen_US
dc.titleChanges in the Bladder After Spinal Cord Injury and Expression of VEGF and APAF-1en_US
dc.titleChanges in the Bladder After Spinal Cord Injury and Expression of VEGF and APAF-1
dc.typeArticleen_US

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