Large granular lymphocytic leukemia

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dc.contributor.authorIşikakdo?an A.
dc.contributor.authorAyyildiz M.O.
dc.contributor.authorTiftik N.
dc.contributor.authorMüftüo?lu E.
dc.date.accessioned2024-04-24T17:58:47Z
dc.date.available2024-04-24T17:58:47Z
dc.date.issued2000
dc.departmentDicle Üniversitesien_US
dc.description.abstractLGL-L is a rare disorder characterized by clonal proliferation of cells with large granular lymphocytes. LGL-L can be divided into two major lineage: T(CD3 +) and NK (CD3 -) which have distinct clinical and prognostic features. T-LGL-L represents 80-85% of the all LGL-L. The disease may occur both in men and women, and mostly affects elderly people. Clinical features of T-LGL-L is characterized by recurrent infection related to neutropenia, hepatosplenomegaly and rheumatoid arthritis. Laboratory findings include positive rheumatoid factor and antinuclear antibody. The clinical presentation of NK-LGL leukemia is more acute than T-LGL leukemia, with B symptoms, massive hepatosplenomegaly, involvement of the gastrointestinal tract, and coagulopathy in most cases. Patients are younger and usually have an aggressive course with multiorgan failure and death within a few months of diagnosis despite multiagent chemotherapy. Occasional patients have a chronic NK-LGL leukemia with a more indolent course similar to T-LGL leukemia.en_US
dc.identifier.endpage58en_US
dc.identifier.issn1016-5134
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-0034437322en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage55en_US
dc.identifier.urihttps://hdl.handle.net/11468/24104
dc.identifier.volume12en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.relation.ispartofSENDROMen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleLarge granular lymphocytic leukemiaen_US
dc.title.alternativeGeniş granüllü lenfositik lösemien_US
dc.typeShort Surveyen_US

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