Can NLR/PLR/CEA be a marker for predicting a complete pathological response in locally advanced rectal cancer?

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dc.authorid0000-0002-3161-0923en_US
dc.contributor.authorÇiyiltepe, Hüseyin
dc.contributor.authorGündeş, Ebubekir
dc.contributor.authorÇetin, Durmuş Ali
dc.contributor.authorAday, Ulaş
dc.contributor.authorBozdağ, Emre
dc.contributor.authorGülmez, Selçuk
dc.contributor.authorUzun, Orhan
dc.contributor.authorSenger, Aziz Serkan
dc.contributor.authorPolat, Erdal
dc.contributor.authorDuman, Mustafa
dc.date.accessioned2021-06-01T11:20:45Z
dc.date.available2021-06-01T11:20:45Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.descriptionWOS:000645097300011
dc.description.abstractAim: The standard treatment for locally advanced (T3-4 and/or N +) rectal cancer (LARC) is Total Mesorectal Excision (TME) and adjuvant chemotherapy after neoadjuvant chemo-radiotherapy (n-CRT). Various clinical or pathological complete response (pCR) rates after neoadjuvant therapy have been reported in the literature. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) or carcinoembryonic antigen (CEA) levels are used as prognostic markers for many tumors.The aim of this study is to investigate the relationship between treatment response and the above markers in patients receiving n-CRT for LARC. Material and Methos: The pathology results of 113 patients who underwent TME after n-CRT were divided into 4 groups according to the modified ryan tumor regression grade (TRG) classification. Among these groups, NLR, PLR and CEA levels, which are considered prognostic markers in response evaluation, were compared with their changes before and after neoadjuvant treatment. Results: While 11 (9,7%) patients had pCR (TRG 0), 41 (36,3%) patients had good response (TRG 0 and 1), 72 (63,7%) patients had a poor response (TRG 2 and 3) to n-CRT. While the initial prognostic markers were similar between the groups, post-n-CRT values were found to be significantly lower in the group with good response. Discussion: It is not possible to predict n-CRT response in LARC patients at the time of diagnosis, but NLR, PLR or CEA values and changes in these values may be useful in predicting treatment response.en_US
dc.identifier.citationÇiyiltepe, H., Gündeş, E., Çetin, D.A., Aday, U., Bozdag, E., Gülmez, S. ve diğerleri. Can NLR/PLR/CEA be a marker for predicting a complete pathological response in locally advanced rectal cancer? Annals of Clinical and Analytical Medicine, 12(1), 49-53.en_US
dc.identifier.doi10.4328/ACAM.20431
dc.identifier.endpage53en_US
dc.identifier.issn2667-663X
dc.identifier.issue1en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://hdl.handle.net/11468/7008
dc.identifier.urihttp://www.bayrakol.org/en/2021/january2021/original-article/item/2540-can-nlr-plr-cea-be-a-marker-for-predicting-a-complete-pathological-response-in-locally-advanced-rectal-cancer
dc.identifier.volume12en_US
dc.identifier.wosWOS:000645097300011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAday, Ulaş
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRectal canceren_US
dc.subjectNeutrophil-to-lymphocyte ratio (NLR)en_US
dc.subjectPlatelet-to-lymphocyte ratio (PLR)en_US
dc.subjectCarcinoembryonic antigen (CEA)en_US
dc.titleCan NLR/PLR/CEA be a marker for predicting a complete pathological response in locally advanced rectal cancer?en_US
dc.titleCan NLR/PLR/CEA be a marker for predicting a complete pathological response in locally advanced rectal cancer?
dc.typeArticleen_US

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