Investigation of the prognostic significance of c-kit and c-erb-b2 expression in osteosarcoma, ewing sarcoma, and rhabdomyosarcoma and comparison with clinical parameters

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dc.contributor.authorAydogdu, Gulay
dc.contributor.authorBilgic, Bilge
dc.contributor.authorKiroglu, Kumru
dc.date.accessioned2024-04-24T17:20:46Z
dc.date.available2024-04-24T17:20:46Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: In the present study, the prognostic and treatment-guiding roles of the c-erb-B2 oncoprotein and tyrosine kinase receptor c-kit in osteosarcoma (OS), Ewing sarcoma (ES), and rhabdomyosarcoma (RMS) were evaluated. Materials and methods: With 25 cases from each group, c-kit and c-erb-B2 expression were investigated immunohistochemically in a total of 75 cases. Results: Staining for c-kit was found to be positive in 15 (60%) of the RMS, 11 of the OS (44%), and 11 of the ES cases (44%). C-erbB-2 staining was positive in 7 RMS cases (8%) and negative in all cases of OS and ES.The SISH method was applied to six c-erb-B2 positive RMS cases, and amplification of the HER2 gene (encoding c-erb-B2) was detected in one case. It was determined that c-kit expression in OS was significantly associated with survival (p<0.05) and could be considered as a poor prognostic parameter. In contrast,c-kit expression had no prognostic significance in ES and RMS. In the RMS group, there was no relationship between c-erb-B2 positivity and prognosis. Conclusion: It was concluded that c-kit expression can be used as a poor prognostic parameter for OS and therapy targeting c-kit may be an alternative treatment option.en_US
dc.identifier.doi10.3306/AJHS.2023.38.05.77
dc.identifier.endpage83en_US
dc.identifier.issn1579-5853
dc.identifier.issn2255-0569
dc.identifier.issue5en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://doi.org/10.3306/AJHS.2023.38.05.77
dc.identifier.urihttps://hdl.handle.net/11468/19236
dc.identifier.volume38en_US
dc.identifier.wosWOS:001106456700012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherReial Acad Medicina Illes Balearsen_US
dc.relation.ispartofMedicina Balear
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOsteosarcomaen_US
dc.subjectEwing Sarcomaen_US
dc.subjectRhabdomyosarcomaen_US
dc.subjectC-Kiten_US
dc.subjectC-Erb-B2en_US
dc.titleInvestigation of the prognostic significance of c-kit and c-erb-b2 expression in osteosarcoma, ewing sarcoma, and rhabdomyosarcoma and comparison with clinical parametersen_US
dc.titleInvestigation of the prognostic significance of c-kit and c-erb-b2 expression in osteosarcoma, ewing sarcoma, and rhabdomyosarcoma and comparison with clinical parameters
dc.typeArticleen_US

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