Serum Ghrelin Levels in Patients with Chronic Urticaria and Atopic Dermatitis and Its Relationship with Metabolic Syndrome

Basit Öğe Kaydı
dc.contributor.authorDemir, B.
dc.contributor.authorCicek, D.
dc.contributor.authorDertlioglu, S.
dc.contributor.authorAydin, S.
dc.contributor.authorUcak, H.
dc.contributor.authorErgin, C.
dc.contributor.authorErden, I.
dc.date.accessioned2024-04-24T17:28:25Z
dc.date.available2024-04-24T17:28:25Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Chronic urticaria is a systemic inflammatory disease. Atopic dermatitis is a chronic immunological disease that is characterized by an increase in systemic inflammatory response. In several studies, chronic urticaria and atopic dermatitis were reported to be associated metabolic syndrome (MetS). In this study, we aimed to investigate the serum ghrelin levels in the patients with chronic urticaria and atopic dermatitis. Methods: Thirty patients with chronic urticaria, 30 patients with atopic dermatitis and 30 control subjects participated in this study. Blood fasting glucose and serum lipids, insulin, C-peptide levels and thyroid function tests were measured. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate insulin resistance. Ghrelin levels were determined by an enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's protocol. Results: The mean serum ghrelin levels in the patients with chronic urticaria (54.13 +/- 40.94 pg/mL) and atopic dermatitis (65.33 +/- 93.54 pg/mL) were significantly higher than those of the controls (30.36 +/- 17.13 pg/mL) (p = 0.003, p = 0.04, respectively). Conclusion: We detected higher serum ghrelin levels in the patients with chronic urticaria and atopic dermatitis than the controls. However, we failed to find any association between serum ghrelin levels and insulin resistance or MetS. We think that the high levels of serum ghrelin in the patients with chronic urticaria and atopic dermatitis may be related to the mechanisms independent of insulin resistance.en_US
dc.identifier.doi10.7727/wimj.2015.392
dc.identifier.endpage31en_US
dc.identifier.issn0043-3144
dc.identifier.issn2309-5830
dc.identifier.issue1en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.7727/wimj.2015.392
dc.identifier.urihttps://hdl.handle.net/11468/20430
dc.identifier.volume70en_US
dc.identifier.wosWOS:001111167400007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherUniv West Indies Faculty Medical Sciencesen_US
dc.relation.ispartofWest Indian Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtopic Dermatitisen_US
dc.subjectChronic Urticariaen_US
dc.subjectGhrelinen_US
dc.titleSerum Ghrelin Levels in Patients with Chronic Urticaria and Atopic Dermatitis and Its Relationship with Metabolic Syndromeen_US
dc.titleSerum Ghrelin Levels in Patients with Chronic Urticaria and Atopic Dermatitis and Its Relationship with Metabolic Syndrome
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu