TIME-DEPENDENT CHANGES IN PLASMA GHRELIN AND ANGIOTENSIN II LEVELS IN THE DIABETIC NEPHROPATHY MODEL

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dc.contributor.authorGul, Cihan
dc.contributor.authorKelle, Mustafa
dc.contributor.authorBaylan, Mukadder
dc.contributor.authorYokus, Beran
dc.contributor.authorTasdemir, Ezel
dc.date.accessioned2024-04-24T17:47:49Z
dc.date.available2024-04-24T17:47:49Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractGhrelin is an appetite-enhancing anabolic hormone secreted from the stomach. Angiotensin II maintains sodium and potassium levels in body fluids and plays a very important role in the regulation of arterial blood pressure. Although their relationship with Type 2 diabetes and complications have been reported, their role in diabetic nephropathy is not fully understood. We investigated time dependent possible changes in plasma ghrelin and angiotensin II levels during the development and progression of diabetic nephropathy in experimental diabetic rat model. Adult 63 male Wistar Albino rats were randomly divided into 9 groups as 4 control (C1-C4), 4 diabetic (D1-D4) and one treatment (T) group. Group D1, sacrificed by cardiac puncture one week after diabetes, group D2 three weeks later, group D3 six weeks later, and groups D4 and T eight weeks later. Antidiabetic treatment was not administered to the D1-D4 group diabetic rats. Group T diabetic rats were treated with antidiabetic metformin (100 mg / kg / day) for 8 weeks. A single dose of 35 mg / kg intraperitoneal streptozotocin was administered to the rats to induce diabetes. Significant differences were found between the D4 and C4 groups in body weight, plasma glucose, ghrelin and angiotensin II, serum and urine creatinine levels. While there was a linear (positive) relationship between plasma ghrelin levels of all rats and urinary creatinine and creatinine clearance and body weight, negative correlations were found between plasma ghrelin and angiotensin II levels and fasting blood glucose levels of all rats. During the progression of diabetes and the development of diabetes-related nephropathy, plasma angiotensin and serum creatinine levels increased, while plasma ghrelin levels decreased over time. Therefore, it was concluded that changes in plasma ghrelin and angiotensin II levels in diabetic rats may be associated with the pathogenesis of diabetic nephropathy.en_US
dc.description.sponsorshipDicle University Scientific Research Projects Coordination Unit [:19.004]en_US
dc.description.sponsorshipThis research has been supported by Dicle University Scientific Research Projects Coordination Unit, Project Number:19.004, Year:2019en_US
dc.identifier.endpage757en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue1en_US
dc.identifier.startpage747en_US
dc.identifier.urihttps://hdl.handle.net/11468/22763
dc.identifier.volume30en_US
dc.identifier.wosWOS:000629181200083
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGhrelinen_US
dc.subjectNephropathyen_US
dc.subjectAngiotensin Iien_US
dc.subjectDiabetesen_US
dc.subjectStreptozotocinen_US
dc.titleTIME-DEPENDENT CHANGES IN PLASMA GHRELIN AND ANGIOTENSIN II LEVELS IN THE DIABETIC NEPHROPATHY MODELen_US
dc.titleTIME-DEPENDENT CHANGES IN PLASMA GHRELIN AND ANGIOTENSIN II LEVELS IN THE DIABETIC NEPHROPATHY MODEL
dc.typeArticleen_US

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