Rosmarinic Acid Ameliorates Deltamethrin Induced Hepatotoxicity and Nephrotoxicity

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dc.contributor.authorYildizhan, Eda
dc.contributor.authorÜlger, Burak Veli
dc.contributor.authorAkkuş, Murat
dc.contributor.authorKatanalp, Ömer Faruk
dc.contributor.authorÖzkorkmaz, Ebru Gökalp
dc.contributor.authorYıldızhan, İbrahim
dc.date.accessioned2025-03-08T18:29:12Z
dc.date.available2025-03-08T18:29:12Z
dc.date.issued2023
dc.departmentDicle Üniversitesi
dc.description.abstractAim: Deltamethrin (DM) is an insecticide and is widely used around the world. Rosmarinic acid (RA) is found in herbs and spices in the Lamiaceae (mint) family and has antioxidant, antiinflammatory and antiapoptotic effects. We objective to examine the protecting efficacy of Rosmarinic acid in preventing the toxic effects of Deltamethrin. Material and Methods: In ours study we used 28 male rats. Group 1: Control group, Group 2: RA group, RA was given 20 mg/kg peroral (p.o.) for 7 days, Group 3: DM group, 35 mg/kg/dose of DM was given 24 hours before sacrification as a single dose by gavage, Group 4: RA+ DM group. Results: BUN, creatinine, AST and ALT values of the RA+DM group were lower than the DM group. TAS and TOS grades were higher in the DM group matched to the RA+DM group. The damage scores of the DM group were higher aacording as those of the RA+DM group. Conclusion: RA has been shown to have predicative influence in the therapy of deltamethrin-induced nephrotoxicity and hepatotoxicity.
dc.identifier.doi10.37990/medr.1197782
dc.identifier.endpage5
dc.identifier.issn2687-4555
dc.identifier.issue2
dc.identifier.startpage400
dc.identifier.urihttps://doi.org/10.37990/medr.1197782
dc.identifier.urihttps://hdl.handle.net/11468/31716
dc.identifier.volume5
dc.language.isoen
dc.publisherTıbbi Kayıtlar Derneği
dc.relation.ispartofMedical Records
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_21250205
dc.subjectDeltamethrin
dc.subjectrosmarinic acid
dc.subjecthepatotoxicity
dc.subjectnephrotoxicity
dc.titleRosmarinic Acid Ameliorates Deltamethrin Induced Hepatotoxicity and Nephrotoxicity
dc.typeArticle

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