The relationship between inflammation markers, positron emission tomography/ /computed tomography parameters and disease prognosis in advanced non-small-cell lung cancer patients

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dc.contributor.authorPirinççi, Esra
dc.contributor.authorOruç, Zeynep
dc.contributor.authorEbinç, Senar
dc.contributor.authorGüzel, Yunus
dc.contributor.authorKömek, Halil
dc.contributor.authorKüçüköner, Mehmet
dc.contributor.authorUrakçı, Zuhat
dc.contributor.authorTaşdemir, Bekir
dc.contributor.authorIşıkdoǧan, Abdurrahman
dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.orcid0009-0008-5307-8342
dc.contributor.orcid0000-0002-7931-2941
dc.contributor.orcid0000-0002-0878-6525
dc.contributor.orcid0000-0002-8555-0460
dc.contributor.orcid0000-0001-8168-136X
dc.contributor.orcid0000-0001-7336-871X
dc.contributor.orcid0000-0003-3878-988X
dc.contributor.orcid0000-0002-7787-0341
dc.contributor.orcid0000-0002-7451-7286
dc.contributor.orcid0000-0003-0882-0524
dc.date.accessioned2024-04-24T17:27:57Z
dc.date.available2024-04-24T17:27:57Z
dc.date.issued2024
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractIntroduction. Inflammation is known to be related to the development, spread, prognosis, and treatment response in cancer patients. Our study aimed to evaluate the correlation between inflammation indices and positron emission tomography-computed tomography (PET/CT) parameters and investigate their relationship with progression-free survival (PFS) and overall survival (OS) in patients diagnosed with stage-IV non -small cell lung cancer (NSCLC). Material and methods. Demographic, clinicopathological, laboratory, and PET/CT data of 179 patients diagnosed with stage-IV NSCLC who presented to the Oncology Department of Dicle University, Faculty of Medicine between 2010-2020 were retrieved from patient files and the hospital database system. Results. The median age at diagnosis was 64 (27-87) years. All patients included in the study had NSCLC: 72.6% had adenocarcinoma, 21.2% had squamous cell carcinoma, and 6.1% had other histological types. Of the 78 patients who were subjected to molecular analysis, 26 (33.3%) were EGFR-mutation positive. During the 10-month median follow-up, median first -line PFS was 6 months (95% CI 5.00-6.99), and median OS was 10 months (95% CI 7.8-12.1). The multivariate analysis performed for first -line PFS determined hemoglobin (HR = 1.01; 95% CI 1.003-1.02; p = 0.005) and PET total lesion glycolysis (TLG) (HR = 1.002; 95% CI 1.001-1.003; p = 0.003) values as independent prognostic factors. The multivariate analysis for OS determined positive EGFR mutation status (HR = 0.385; 95% CI 0.213-0.696; p = 0,014) and performance status (HR = 1.88; 95% CI 1.092-3.238; p = 0,008) as independent prognostic factors. Conclusions. Our study determined the hemoglobin level and PET TLG from PET/CT parameters to be independent prognostic factors for PFS, and performance status and EGFR mutation positivity to be independent prognostic factors for OS.en_US
dc.identifier.citationPirinççi, E., Oruç, Z., Ebinç, S., Güzel, Y., Kömek, H., Küçüköner, M. ve diğerleri. (2024). The relationship between inflammation markers, positron emission tomography/ /computed tomography parameters and disease prognosis in advanced non-small-cell lung cancer patients. Oncology in Clinical Practice, 20(4), 245-254.
dc.identifier.doi10.5603/ocp.97451
dc.identifier.issn2450-1654
dc.identifier.issn2450-6478
dc.identifier.urihttps://doi.org/10.5603/ocp.97451
dc.identifier.urihttps://hdl.handle.net/11468/20270
dc.identifier.urihttps://journals.viamedica.pl/oncology_in_clinical_practice/article/view/97451
dc.identifier.wosWOS:001170994000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofOncology in Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectNon-Small-Cell lung canceren_US
dc.subjectPet/Cten_US
dc.titleThe relationship between inflammation markers, positron emission tomography/ /computed tomography parameters and disease prognosis in advanced non-small-cell lung cancer patientsen_US
dc.titleThe relationship between inflammation markers, positron emission tomography/ /computed tomography parameters and disease prognosis in advanced non-small-cell lung cancer patients
dc.typeArticleen_US

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