Dietary addition of caffeic acid phenethyl ester protects myocardial tissue against ethambutol induced oxidative stress

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dc.contributor.authorYavuz C.
dc.contributor.authorDemirta S.
dc.contributor.authorYazici S.
dc.contributor.authorÇalikan A.
dc.contributor.authorGüçlü O.
dc.contributor.authorKarahan O.
dc.contributor.authorMavitaş B.
dc.date.accessioned2024-04-24T18:43:41Z
dc.date.available2024-04-24T18:43:41Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The myocardial effect of ethambutol (ETM) has not yet been clarified. The main purpose of this study was to determine both the oxidative status in myocardial tissue after administration of ETM and the adjuvant benefits of caffeic acid phenethyl ester (CAPE). Material and Method: Twenty four male rats were divided into three experimental groups as follows: a control group (without any drug administration) was created for obtaining normal myocardial tissue; an ETM group (rats received only ETM for thirty days) was created for ethambutol administration; and an ETM+CAPE group was created for administration of the full regimen (rats received ETM+CAPE for thirty days). Rats were sacrified at the end of day 30 and heart tissues were obtained for histopathological and biochemical examination. Oxidant and antioxidant parameters were biochemically investigated in all tissue samples. Results: In the ETM group, myocardial malondialdehyde (MDA) levels and total oxidant status (TOS) were significantly higher than in the control group (p<0.001). Conversely, total antioxidant capacity (TAC), the activity of superoxide dismutase (SOD) and of serum paraoxonase (PON1) were reduced in the ETM group (p<0.05). Furthermore, MDA and TOS activity was significantly reduced in the ETM+CAPE group (p<0.05); TAC, SOD, and PON1 activities were increased with adjuvant CAPE therapy (in the ETM+CAPE group) rather than in the ETM group. Conclusion: ETM may lead to increased myocardial oxidative stress due to lipid peroxidation. Nevertheless, adjuvant CAPE administration seems to provide a partial enhancement of myocardial damage.en_US
dc.identifier.endpage124en_US
dc.identifier.issn1305-2381
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84891700689en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://hdl.handle.net/11468/24294
dc.identifier.volume9en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofNobel Medicusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCape Compounden_US
dc.subjectEthambutolen_US
dc.subjectMyocardiumen_US
dc.subjectOxidative Stressen_US
dc.titleDietary addition of caffeic acid phenethyl ester protects myocardial tissue against ethambutol induced oxidative stressen_US
dc.title.alternativeKafeik asit fenetil esterin diyete eklenmesi etambutol kaynakli oksidatif strese karşi tedavisinin miyokard dokusunu koruren_US
dc.typeArticleen_US

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