Comparative preventive efficacy of recombinant tissue plasminogen activator (rt-PA), urokinase, hyaluronic acid and enoxaparin in post laminectomy epidural fibrosis in rats

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dc.contributor.authorKemaloğlu S.
dc.contributor.authorGür A.
dc.contributor.authorYilmaz F.
dc.contributor.authorAcemoğlu H.
dc.contributor.authorÖzkan U.
dc.date.accessioned2024-04-24T18:43:44Z
dc.date.available2024-04-24T18:43:44Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: We aimed to determine the effects of rt-PA and enoxaparin on post laminectomy epidural fibrosis and to compare the effects of these two medications with hyaluronic acid and urokinase in an experimental model of spinal epidural fibrosis. Method: Forty Spraque-Dawley rats were anaesthetized by intraperitoneal anesthesia (ketamin 8 mg/100 g) and randomly allocated to five groups. All groups were underwent L1-2 total laminectomies. Topical medications were applied to group 2-5 right after the laminectomy space. Hence, in group 1 (G1=control) only laminectomy was constituted, in group 2 (G2) laminectomy + topical Urokinase, in group 3 (G3) laminectomy + topical rt-PA, in group 4 (G4) laminectomy + topical enoxaparin and in group 5 laminectomy + topical Hyaluronic acid (G5) application were performed. The potentials of local urokinase, rt-PA, hyaluronic acid and enoxaparin in preventing the production of epidural fibrosis were assessed. Result: In inter group comparison, G1-G2, G1-G3, G1-G4, G1-G5 groups differed from each other for total scar score, middle scar score and deep scar score (p<0.05). However, G2-G3, G2-G4, G2-G5, G3-G4, G3-G5 and G4-G5 were not different from each other. Conclusion: In rats, the topical thrombolysis with fibrinolitic agents is safe and efficacious in preventing of post laminectomy epidural fibrosis. Thrombolytic therapy with topical hyaluronic acid, rt-PA, urokinase and enoxaparin may come to play an important role in the prevention of post operative spinal epidural fibrosis and arachnoiditis. Based on the results we found that rt-PA and enoxaparine inhibit the formation of epidural scar adhesions and arachnoiditis compared with control group.en_US
dc.identifier.endpage175en_US
dc.identifier.issn1304-3889
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-80054102291en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage170en_US
dc.identifier.urihttps://hdl.handle.net/11468/24336
dc.identifier.volume8en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTIP ARASTIRMALARI DERNEGIen_US
dc.relation.ispartofEuropean Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArachnoiditisen_US
dc.subjectEnoxaparinen_US
dc.subjectEpidural Fibrosisen_US
dc.subjectHyaluronic Aciden_US
dc.subjectRaten_US
dc.subjectRt-Paen_US
dc.subjectUrokinaseen_US
dc.titleComparative preventive efficacy of recombinant tissue plasminogen activator (rt-PA), urokinase, hyaluronic acid and enoxaparin in post laminectomy epidural fibrosis in ratsen_US
dc.title.alternativeRatlarda rt-PA, Urokinase, Hyaluronic Acid ve Enoxaparin'in Postlaminektomi Epidural Fibrosisi önleyici Etkilerinin Karşılaştırmalı incelenmesien_US
dc.typeArticleen_US

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