Cytotoxic potential of selenium nanoparticles (SeNPs) derived from leaf extract of Mentha longifolia L.

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dc.contributor.authorİpek, Polat
dc.contributor.authorBaran, Ayşe
dc.contributor.authorHatipoğlu, Abdülkerim
dc.contributor.authorBaran, Mehmet Fırat
dc.date.accessioned2025-03-08T18:27:47Z
dc.date.available2025-03-08T18:27:47Z
dc.date.issued2024
dc.departmentDicle Üniversitesi
dc.description.abstractThe search for alternative methods in cancer treatments has been going on for many years. In the current study conducted for this purpose, selenium nanoparticles (ML-SeNPs) were produced from the aqueous leaf extract of Mentha longifolia L. easily and inexpensively, without harming the environment. The anticancer potential of ML-SeNPs on glioblastoma cell (U373), osteosarcoma cell (U2OS), and healthy retinal pigment epithelial cell (RPE-1) lines was determined by MTT (3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolium bromid) test. For the test, ML-SeNPs were applied at 100, 300, and 600 µg/mL levels and interaction was provided for 24 and 48 hours. The survival rates (%) in RPE-1, U373, and U2OS cell lines in the 24-hour application were 107.49-98.89, 97.66-86.82, and 87.81-83.37, respectively. The viability rates (%) of the cells in 48 hours of application were 72.27-87.39, 68.17-73.48, and 81.00-84.67, respectively. In general, it was discovered that the cytotoxic effect of ML-SeNPs on RPE-1, U373, and U2OS cell lines was greater at low doses and increased over time. In-vivo studies that support the antiproliferative action of ML-SeNPs may boost the prospect of using them as therapeutic agents in potential cancer treatment procedures in the following years.
dc.identifier.doi10.31015/jaefs.2024.1.17
dc.identifier.endpage175
dc.identifier.issn2618-5946
dc.identifier.issue1
dc.identifier.startpage169
dc.identifier.urihttps://doi.org/10.31015/jaefs.2024.1.17
dc.identifier.urihttps://hdl.handle.net/11468/31223
dc.identifier.volume8
dc.language.isoen
dc.publisherGültekin ÖZDEMİR
dc.relation.ispartofInternational Journal of Agriculture Environment and Food Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_21250205
dc.subjectAnticancer
dc.subjectMentha longifolia L.
dc.subjectSeNPs
dc.subjectU373
dc.subjectU2OS
dc.titleCytotoxic potential of selenium nanoparticles (SeNPs) derived from leaf extract of Mentha longifolia L.
dc.typeArticle

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