Comprehensively revealing the profile of Pistacia vera L. cv. Siirt Turpentine - Antioxidant, Antidiabetic, Anti-Alzheimer, and Antiglaucoma effects

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dc.contributor.authorKarageçili, Hasan
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorAlwasel, Saleh H.
dc.contributor.authorArık, Mustafa
dc.contributor.authorGülçin, İlhami
dc.date.accessioned2024-04-24T17:58:13Z
dc.date.available2024-04-24T17:58:13Z
dc.date.issued2023
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalıen_US
dc.description.abstractPistacia species containing turpentine which has protective effects and used as a medicine against diabetes, and infections for a long time. To interpret the antioxidant capacities of turpentine from Pistacia vera L. cv. Siirt, 2,2’-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid radical (ABTS•+) and 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH?), Fe3+-2,4,6-tris(2-pyridyl)-S-triazine (TPTZ) and Cu2+ reducing ability were studied and compared to reference antioxidants of BHT, BHA, ?-Tocopherol, and Trolox. The IC50 of turpentine for ABTS•+ and DPPH? scavenging capacities were determined to be lower than reference antioxidant standards as 231.1 ?g/mL and 346.6 ?g/mL, consequently. The total flavonoid and phenolic contents in turpentine were measured as 12.5 mg GAE/g and 38.852 mg QE/g, respectively. For determination of antidiabetic, anti-Alzheimer, and antiglaucoma effects of turpentine, acetylcholinesterase (AChE), ?-glycosidase and carbonic anhydrase II (hCA II) enzymes inhibition abilities of turpentine were performed. The IC50 values of turpentine extract against ?-glycosidase, hCA II, and AChE enzymes were found as 2.04, 3.59 and 14.6 µg/mL, respectively. The quantity of protocatechuic acid and naringenin were determined using LC-MS/MS against 53 standards. The results clearly demonstrated polyphenolics in P. vera L. cv. Siirt turpentine is a natural product has potential usage in amelioration of glaucoma, AD, diabetes, and epilepsy.en_US
dc.description.sponsorshipKing Saud University, KSUen_US
dc.description.sponsorshipS. Alwasel would like to extend his sincere appreciation to the Researchers Supporting Project (RSP-2023/59), King Saud University, Saudi Arabia, for support.en_US
dc.identifier.citationKarageçili, H., Yılmaz, M. A., Alwasel, S. H., Arık, M. ve Gülçin, İ. (2023). Comprehensively revealing the profile of Pistacia vera L. cv. Siirt Turpentine - Antioxidant, Antidiabetic, Anti-Alzheimer, and Antiglaucoma effects. Records of Natural Products, 17(5), 918-937.
dc.identifier.doi10.25135/rnp.410.2305.2787
dc.identifier.endpage937en_US
dc.identifier.issn1307-6167
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85171523228
dc.identifier.scopusqualityQ2
dc.identifier.startpage918en_US
dc.identifier.urihttps://doi.org/10.25135/rnp.410.2305.2787
dc.identifier.urihttps://hdl.handle.net/11468/23719
dc.identifier.volume17en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherACG Publicationsen_US
dc.relation.ispartofRecords of Natural Products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectAntioxidanten_US
dc.subjectCarbonic anhydraseen_US
dc.subjectPhenolic compoundsen_US
dc.subjectTurpentineen_US
dc.subject?-Glycosidaseen_US
dc.titleComprehensively revealing the profile of Pistacia vera L. cv. Siirt Turpentine - Antioxidant, Antidiabetic, Anti-Alzheimer, and Antiglaucoma effectsen_US
dc.titleComprehensively revealing the profile of Pistacia vera L. cv. Siirt Turpentine - Antioxidant, Antidiabetic, Anti-Alzheimer, and Antiglaucoma effects
dc.typeArticleen_US

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