Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility

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dc.contributor.authorOğlak, Süleyman Cemil
dc.contributor.authorEge, Serhat
dc.contributor.authorOtçu, Serap Mutlu Özçelik
dc.contributor.authorObut, Mehmet
dc.contributor.authorKahveci, Bekir
dc.contributor.authorYıldız, İsmail
dc.contributor.authorSakar, Mehmet Nafi
dc.date.accessioned2024-04-24T19:11:49Z
dc.date.available2024-04-24T19:11:49Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study aimed to determine the outcomes of combined treatment of letrozole (LTZ) with recombinant follicle -stimulating hormone (rFSH) in comparison with rFSH alone in intrauterine insemination (IUI) cycles.This study consisted of 86 patients who experienced 106 IUI cycle s. Patients were classified into two treatment groups:group I underwent a combination of LTZ plus rFSH, and group II received rFSH alone. Ovulation was triggered withhuman chorionic gonadotropin (hCG), and IUI performed 36 hours later. The number of follicles ?18 mm, endometrialthickness, required dose of FSH, duration of ovulation induction (OI), clinical pregnancy rates, multiple pregnancy rates,spontaneous abortion rates, and live birth rates were evaluated.The total required rFSH dose during the OI was significantly lower in the LTZ-rFSH combination group than the rFSHalone group (401.2±177.1 IU and 770.1±345.8 IU, respectively, p<0.001). The days of stimulation with rFSH were alsolower in the LTZ co-treatment group than the rFSH-alone group (5.2±1.3 days and 10.1±3.0 days, respectively, p<0.001).Clinical pregnancy rate was 17.0% in LTZ-rFSH group, and 15.2% in rFSH group (p>0.05).The combined use of LTZ with rFSH resulted in a lower required dose of rFSH, a similar and ac ceptable endometrialthickness at the day of hCG administration, and comparable pregnancy rate compared with rFSH aloneen_US
dc.identifier.doi10.5505/ejm.2020.24993
dc.identifier.endpage433en_US
dc.identifier.issn1301-0883
dc.identifier.issn1339-3886
dc.identifier.issue3en_US
dc.identifier.startpage427en_US
dc.identifier.trdizinid377237
dc.identifier.urihttps://doi.org/10.5505/ejm.2020.24993
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/377237
dc.identifier.urihttps://hdl.handle.net/11468/28214
dc.identifier.volume25en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofEastern Journal of Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleComparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertilityen_US
dc.titleComparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility
dc.typeArticleen_US

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