Quantitative analysis of t(8,21) and inv(16) via RT-PCR in patients with acute myeloid leukemia

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dc.contributor.authorAyyildiz O.
dc.contributor.authorKalkanli S.
dc.contributor.authorBatun S.
dc.contributor.authorIşikdo?an A.
dc.contributor.authorSöker M.
dc.contributor.authorYurt M.
dc.contributor.authorMüftüo?lu E.
dc.date.accessioned2024-04-24T17:58:34Z
dc.date.available2024-04-24T17:58:34Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractIt has been showed that there is a relation between chromosomal abnormality and prognosis in acute myeloid leukemia (AML). There are many chromosomal abnormalities in AML patients and it is known that t(8;21) and inv(16) are good prognostic abnormalities. Recently the treatment has been planned according to these abnormalities. We investigated t(8,21) and inv(16) abnormalities by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) in 19 patients with AML. Morever conventional cytogenetic method was applied for all patients. Of whom 9 were men and 10 women. Age of avarage was 19 to 58 years. FAB morphologic classification follows as; 5 AML-M1, 8 AML-M2, 5 AML-M4, 1 AML-M5. Complete remission was obtained in eighteen patients with first induction regimen, whereas in one patient after second induction. t(8;21) has been found in 1 patient with cytogenetic method and confirmed with RT-PCR. In this study, we aim to search t(8;21) and inv(16) abnormalities in AML cases.en_US
dc.identifier.endpage17en_US
dc.identifier.issn1301-8825
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-16844368695
dc.identifier.scopusqualityN/A
dc.identifier.startpage15en_US
dc.identifier.urihttps://hdl.handle.net/11468/23997
dc.identifier.volume15en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.relation.ispartofTHOD - Turk Hematoloji-Onkoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Myeloid Leukemiaen_US
dc.subjectInv(16)en_US
dc.subjectQuantitative Reverse Transcription Polymerase Chain Reactionen_US
dc.subjectT(8;21)en_US
dc.titleQuantitative analysis of t(8,21) and inv(16) via RT-PCR in patients with acute myeloid leukemiaen_US
dc.titleQuantitative analysis of t(8,21) and inv(16) via RT-PCR in patients with acute myeloid leukemia
dc.title.alternativeAkut myeloid lösemili hastalarimizda t(8;21) ve inv (16)'nin kantitatif RT-PCR ile araştirilmasien_US
dc.title.alternativeAkut myeloid lösemili hastalarimizda t(8;21) ve inv (16)'nin kantitatif RT-PCR ile araştirilmasi
dc.typeArticleen_US

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