Proliferative Effect of Gum Tragacanth on Different Cancer Cells

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dc.contributor.authorİrtegün Kandemir, Sevgi
dc.contributor.authorJahan, Israt
dc.contributor.authorTeke, Fatma
dc.date.accessioned2025-02-22T14:17:58Z
dc.date.available2025-02-22T14:17:58Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractGum tragacanth (GT) is a natural plant exudate discharged from the twigs and stems of Asiatic species of the Astragalus genus. GT is a heterogeneous polysaccharide which has been utilized in various biomedical fields and traditionally in ethnomedicine because of its distinctive physicochemical and biological properties, such as great biocompatibility, thermal stability biodegradability, hydrophilicity and antioxidant activity. The aim of this study was to examine whether GT has cytotoxic effects on various cancer cell lines. For this aim, four cancer cell lines i.e., human colorectal adenocarcinoma (CACO-2), glioblastoma multiforme tumor (T98G), ovarian sarcoma (SKOV-3), and breast cancer (MCF-7) cells were used. GT was prepared at the concentration of 200 µg/mL, 100 µg/mL, 50 µg/mL, 25 µg/mL and 12.5 µg/mL, using both 5% DMSO and dH2O as solvent. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) colorimetric assay was used for in vitro cytotoxicity study. GT had no cytotoxic effect on these cancer cells since cell viability percentages were found to be above 80% for all the treatments. However, remarkable dose-dependent cell proliferation efficiency of GT at certain concentrations was observed on all cancer cells except MCF-7. In conclusion, this study suggests that cancer patients should be careful about the use of GT or products containing GT due to the increasing effect of GT on the proliferation of cancer cells.en_US
dc.identifier.doi10.21597/jist.1295606
dc.identifier.endpage74en_US
dc.identifier.issn2146-0574
dc.identifier.issn2536-4618
dc.identifier.issue1en_US
dc.identifier.startpage66en_US
dc.identifier.trdizinid1226850en_US
dc.identifier.urihttps://doi.org/10.21597/jist.1295606
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1226850
dc.identifier.urihttps://hdl.handle.net/11468/30163
dc.identifier.volume14en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofIğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_TR_20250222
dc.subjectCytotoxicityen_US
dc.subjectCell proliferationen_US
dc.subjectMTT assayen_US
dc.subjectGum tragacanth (GT)en_US
dc.subjectCancer cellen_US
dc.titleProliferative Effect of Gum Tragacanth on Different Cancer Cellsen_US
dc.typeArticleen_US

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