The Role of FLT3-ITD and CCAAT-Enhancer-Binding Protein ? Mutations on Prognosis of Acute Lymphoblastic Leukaemia in Turkish Patients

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dc.contributor.authorUluca U.
dc.contributor.authorSöker M.
dc.contributor.authorAyyıldız M.O.
dc.contributor.authorYurt M.
dc.contributor.authorŞen V.
dc.contributor.authorYel S.
dc.contributor.authorGüneş A.
dc.date.accessioned2024-04-24T17:58:33Z
dc.date.available2024-04-24T17:58:33Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Acute lymphoblastic leukaemia (ALL) is the most common malignancy in childhood. Although some prognostic factors have been defined to date, the estimation of prognosis is currently not perfect. Previous studies had shown an association of FLT3 with poor prognosis and CCAAT-enhancer-binding protein ? (CEBPA) mutation with the development of acute myeloid leukaemia (AML). Here, we aimed to evaluate the prognostic value of FLT3-ITD and CEBPA mutations in ALL. Methods: Sixty-one patients with ALL were included in the study. The patients were divided into three risk groups according to BFM risk classification. All of the patients were examined for FLT3-ITD mutations and 45 of them for CEBPA mutations. Mutation positive and negative patients were compared in terms of their risk groups, translocations and cell lineage. The clinical courses of the patients were appraised. Results: FLT3-ITD mutation was detected in 3 of the 61 patients, and CEBPA mutations were detected in 11 of the 45 patients. The incidence of established prognostic indicators including BFM risk classification, t(9; 22); BCR-ABL, t(1; 19); E2A-PBX1, t(12; 21); TEL-AML1, t(4; 11); MLL-AF4 were similar between FLT3-ITD and CEBPA positive and negative patients. A patient with an FLT3-ITD mutation was very susceptible to pancytopenia after maintenance treatment and two other patients with FLT3-ITD mutations were more prone to febrile neutropenia. Conclusion: Our results suggested that CEBPA or FLT3-ITD mutations might not be related to ALL prognosis in the sampled Turkish patients. However, FLT3-ITD mutation might have an influence on the response of bone marrow to chemotherapy. © West Indian Medical Journal 2022. This is an article published in open access under a Creative Commons Attribution International licence (CC BY). For more information, please visit https://creativecommons.org/licenses/by/4.0/deed.en_USen_US
dc.identifier.doi10.7727/wimj.2015.446
dc.identifier.endpage498en_US
dc.identifier.issn0043-3144
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85131444838
dc.identifier.scopusqualityQ4
dc.identifier.startpage494en_US
dc.identifier.urihttps://doi.org/10.7727/wimj.2015.446
dc.identifier.urihttps://hdl.handle.net/11468/23981
dc.identifier.volume69en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherUniversity of the West Indiesen_US
dc.relation.ispartofWest Indian Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Lymphoblastic Leukaemiaen_US
dc.subjectCcaat Enhancer Binding Protein ?en_US
dc.subjectFlt3en_US
dc.subjectMutationen_US
dc.subjectPrognosisen_US
dc.titleThe Role of FLT3-ITD and CCAAT-Enhancer-Binding Protein ? Mutations on Prognosis of Acute Lymphoblastic Leukaemia in Turkish Patientsen_US
dc.titleThe Role of FLT3-ITD and CCAAT-Enhancer-Binding Protein ? Mutations on Prognosis of Acute Lymphoblastic Leukaemia in Turkish Patients
dc.typeArticleen_US

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