Chemical Content by LC-MS/MS, Antiglaucoma, and Antioxidant Activity of Propolis Samples From Different Regions of Türkiye

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dc.authoridYILMAZ, Mustafa Abdullah/0000-0002-4090-7227
dc.authoridIZOL, Ebubekir/0000-0003-0788-4999
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridYilmaz, isa/0000-0001-6796-577X
dc.contributor.authorIzol, Ebubekir
dc.contributor.authorBursal, Ercan
dc.contributor.authorYapici, Ismail
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorYilmaz, Isa
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2025-02-22T14:08:51Z
dc.date.available2025-02-22T14:08:51Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractPropolis is a sticky substance produced by bees because of the reaction of beeswax, pollen, and bee enzymes. Particularly, their biological activity and chemical content attract attention. Thus, in this study, the total amount of phenolic and flavonoid substances, Fe3+-Fe2+, Cu2+ (cupric ions reducing activity [CUPRAC]), and Fe3+-TPTZ (ferric ions reducing antioxidant power [FRAP]) reducing, and DPPH center dot and ABTS center dot+ scavenging assays in vitro antioxidant properties of propolis samples obtained from four different provinces of T & uuml;rkiye were determined. In addition, the chemical content of propolis samples was quantitatively determined by LC-MS/MS, and the antiglaucoma property was revealed by hCAII enzyme inhibition. Propolis samples from Ordu presented the highest amounts of total phenolic and flavonoid content (492.3 +/- 5.8 and 96.1 +/- 2.1, respectively) and also highest antioxidant activity (DPPH center dot and ABTS center dot+ IC50 [mu g/mL]: 8.884 +/- 0.84 and 4.589 +/- 0.80, respectively; Fe+3, CUPRAC, and FRAP: 1.051 +/- 0.012, 1.021 +/- 0.008, and 0.957 +/- 0.007 mu g/mL, respectively). hCAII enzyme inhibition was highest in Mu & scedil; propolis (IC50 [mu g/mL]: 8.6) as determined. By LC-MS/MS, 53 different components were screened and 35 bioactive components were determined. According to the results, propolis was found to be a raw material because it contains high concentrations of acacetin, chrysin, caffeic acid, and quinic acid (123.824, 24.759, 47.779, and 16.32 mg analyte/g extract, respectively).en_US
dc.identifier.doi10.1155/2024/7488590
dc.identifier.issn0145-8884
dc.identifier.issn1745-4514
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1155/2024/7488590
dc.identifier.urihttps://hdl.handle.net/11468/29675
dc.identifier.volume2024en_US
dc.identifier.wosWOS:001350795200003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Food Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectantiglaucomaen_US
dc.subjectantioxidanten_US
dc.subjectchemical contenten_US
dc.subjectLC-MS/MSen_US
dc.subjectpropolisen_US
dc.titleChemical Content by LC-MS/MS, Antiglaucoma, and Antioxidant Activity of Propolis Samples From Different Regions of Türkiyeen_US
dc.typeArticleen_US

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