Effects of sodium nitroprusside on ischemia-reperfusion injury
| dc.contributor.author | Yavuz C. | |
| dc.contributor.author | Çakir O. | |
| dc.contributor.author | Göz M. | |
| dc.contributor.author | Kale E. | |
| dc.contributor.author | Uzunlar A.K. | |
| dc.date.accessioned | 2024-04-24T18:44:19Z | |
| dc.date.available | 2024-04-24T18:44:19Z | |
| dc.date.issued | 2010 | |
| dc.department | Dicle Üniversitesi | en_US |
| dc.description.abstract | Aim: The aim of this study was to investigate the effects of sodium nitroprussid (SNP) on ischemia-reperfusion injury in rats. Method: Twenty-four Sprague-Dawney rats were divided into four equal groups: group I without ischemia-reperfusion (I-R); group II with ischemia; group III with I-R; group IV with I-R and SNP. Complete bilateral hindlimb ischemia was produced by means of tourniquet occlusion of the upper thigh. Result: Blood creatine phosphokinase, lactate dehydrogenase, aspartate transaminase, urea, creatinine levels were not significantly different between groups 3 and 4. Malondialdehyde (MDA) levels were not significantly different between groups 3 and 4 in liver, soleus muscles and lung tissue. However, MDA levels were significantly lower in group 4 when compared with group 3 in renal tissue. Histological examination of the soleus muscles revealed that neutrophil leukocyte infiltration in group 3 was significantly less prominent than in group 4. Conclusion: These results have shown that SNP was not able to improve muscle ischemia-reperfusion injury in our study. | en_US |
| dc.identifier.endpage | 80 | en_US |
| dc.identifier.issn | 1304-3889 | |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.scopus | 2-s2.0-78650267449 | |
| dc.identifier.scopusquality | N/A | |
| dc.identifier.startpage | 76 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11468/24651 | |
| dc.identifier.volume | 7 | en_US |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | en_US |
| dc.publisher | TIP ARASTIRMALARI DERNEGI | en_US |
| dc.relation.ispartof | European Journal of General Medicine | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Ischemia | en_US |
| dc.subject | Reperfusion | en_US |
| dc.subject | Sodium Nitroprusside | en_US |
| dc.title | Effects of sodium nitroprusside on ischemia-reperfusion injury | en_US |
| dc.title | Effects of sodium nitroprusside on ischemia-reperfusion injury | |
| dc.type | Article | en_US |
