Effect of Caffeic Acid Phenethyl Ester on Cerebellar Tissue Damage Secondary to Methanol Intoxication: Experimental Study

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dc.contributor.authorArikanoglu, Adalet
dc.contributor.authorYuksel, Hatice
dc.contributor.authorGocmez, Cuneyt
dc.contributor.authorUzar, Ertugrul
dc.contributor.authorAcar, Abdullah
dc.contributor.authorAluclu, Mehmet Ufuk
dc.date.accessioned2024-04-24T17:24:29Z
dc.date.available2024-04-24T17:24:29Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Previous studies have shown the role of oxidative stress in methanol neurotoxicity. CAPE is known to have an antioxidant property that is shown in many experimental studies. In this study, we aimed to investigate whether CAPE has a protective effect against oxidative stress observed in the cerebellar tissue in methanol intoxication. Material and Method: In this study, a total of 40 rats were split into 5 groups: control group (n=8), MTX-alone group (n=8), MTX+methanol group (n=8), MTX+methanol+ethanol group (ethanol group) (n=8), and MTX+metanol+CAPE group (CAPE group) (n=8). All the rats except the control group were delivered methotrexate (MTX) therapy (0.3 mg/kg/day, via i. p. route) for 7 days in order to induce methanol toxicity. The control group received no drug therapy. Seven days later, 3 g/kg (i.p.) methanol was delivered in the ethanol and CAPE groups. Four hours after the delivery of methanol, ethanol group received 0.5 g/kg ethanol (i.p.) and CAPE group received 10 mu mol/kg CAPE (i.p.), while the other groups were delivered only saline (i.p.). The rats were decapitated after 8 hours and the cerebellar tissues were removed. PON-1, TAS, and MDA levels were measured in the tissues. Results: MTX-alone group demonstrated decreased TAS and PON-1 levels (p=0.001 and p=0.004, respectively) and increased MDA level (p=0.001), as compared to the control group. When MTX+methanol group was compared with the MTX-alone group, MTX+methanol group was found to have decreased TAS and PON-1 activities (p=0.037 and p=0.046, respectively) and increased MDA level (p=0.022). The ethanol group was found to show a significant decrease in MDA level (p=0.001), as compared with the MTX+methanol group. The CAPE group exhibited increased TAS and PON-1 levels (p=0.001 and p=0.001, respectively) and decreased MDA levels, as compared with the MTX+methanol group. Discussion: Cerebellum demonstrates oxidative stress secondary to methanol intoxication. CAPE therapy is more effective against cerebellar oxidative stress than ethanol therapy.en_US
dc.identifier.doi10.4274/Tnd.21939
dc.identifier.endpage96en_US
dc.identifier.issn1301-062X
dc.identifier.issn1309-2545
dc.identifier.issue3en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.4274/Tnd.21939
dc.identifier.urihttps://hdl.handle.net/11468/19702
dc.identifier.volume19en_US
dc.identifier.wosWOS:000217541300004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherTurkish Neurological Socen_US
dc.relation.ispartofTurkish Journal of Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerebellumen_US
dc.subjectOxidative Stressen_US
dc.subjectMethanolen_US
dc.subjectEthanolen_US
dc.subjectCapeen_US
dc.titleEffect of Caffeic Acid Phenethyl Ester on Cerebellar Tissue Damage Secondary to Methanol Intoxication: Experimental Studyen_US
dc.titleEffect of Caffeic Acid Phenethyl Ester on Cerebellar Tissue Damage Secondary to Methanol Intoxication: Experimental Study
dc.typeArticleen_US

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