Correlation of mean platelet volume, neutrophil-to-lymphocyte ratio, and disease activity in children with juvenile ıdiopathic arthritis

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dc.contributor.authorGüneş A.
dc.contributor.authorEce A.
dc.contributor.authorŞen V.
dc.contributor.authorUluca Ü.
dc.contributor.authorAktar F.
dc.contributor.authorTan İ.
dc.contributor.authorYel S.
dc.date.accessioned2024-04-24T18:46:00Z
dc.date.available2024-04-24T18:46:00Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractJuvenile idiopathic arthritis (JIA) is a chronic inflammatory arthritis characterized by periods of remission and relapse. Mean platelet volume (MPV) is an indicator of systemic inflammation. In the present study, we aimed to determine the association between mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), platelet distribution width (PDW) and clinical measures of diseases activity in children with JIA. The study included 115 patients with JIA (64 with active disease and 51 with inactive disease) and 64 age-gender matched healthy control subjects. Routine laboratory methods were used to measure white blood cell count (WBC), platelet count (PLT), neutrophil count, lymphocyte count, hemoglobin (Hb), MPV, PDW, NLR, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) in all subjects of both the patient and control groups. Active disease was associated with significantly increased MPV (8.23 ± 1.16 fl) compared with inactive disease (7.00 ± 1. 08 fl) and control subjects (6.77 ± 1.08 fl) P<0.001, P<0.001, P=NS, respectively). NLR was significantly higher in patients with active (2.11 ± 1.19) and inactive (2.03 ± 1.51) disease relative to the control subjects (1.33 ± 0.66) (P<0.001, P=0.017, respectively). Mean PDW was significantly higher in patients with active disease (17.84 ± 1.06) compared with the control group (17.19 ± 0.93) (P=0.01). Our results suggest that MPV may be a useful marker of disease activity in patients with JIA. Regular treatment may decrease platelet activation in JIA patients. However, NLR was not a predictive marker of disease activity in patients with JIA. © 2015, E-Century Publishing Corporation. All rights reserved.en_US
dc.identifier.endpage11341en_US
dc.identifier.issn1940-5901
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-84940676071
dc.identifier.scopusqualityN/A
dc.identifier.startpage11337en_US
dc.identifier.urihttps://hdl.handle.net/11468/25010
dc.identifier.volume8en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherE-Century Publishing Corporationen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectDisease Activityen_US
dc.subjectJuvenile İdiopathic Arthritisen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectNeutrophil To Lymphocyte Ratioen_US
dc.titleCorrelation of mean platelet volume, neutrophil-to-lymphocyte ratio, and disease activity in children with juvenile ıdiopathic arthritisen_US
dc.titleCorrelation of mean platelet volume, neutrophil-to-lymphocyte ratio, and disease activity in children with juvenile ıdiopathic arthritis
dc.typeArticleen_US

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