Effect of korean red ginseng on colon anastomotic healing: A randomised controlled experimental study

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dc.contributor.authorTali, Ufuk
dc.contributor.authorKafadar, Mehmet Tolga
dc.contributor.authorComert, Mustafa
dc.date.accessioned2024-04-24T17:24:38Z
dc.date.available2024-04-24T17:24:38Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: Although vegetable medicinal products are used worldwide, their beneficial and harmful effects have not been well documented. The aim of this study was to assess the effect of Korean red ginseng (KRG) on the healing of experimental colonic anastomosis in a rat model. Material and Methods: Forty rats were randomized into four groups as follows: control groups (A and B) and KRG groups (C and D). Surgical procedure consisted of a transection and handsewn anastomosis of the ascending colon. Animals daily received either KRG (50m1/kg) or an equal volume of water by gavages 5 days before operation and then the surgery was done. Rats in Groups A and C were sacrificed on postoperative day (POD) 3, rats in Groups B and D were sacrificed on POD 7. Anastomotic complications and anastomotic bursting pressure measurements were recorded. Following these measurements, the anastomotic segment was resected for hydroxyproline (HPO) and histopathological evaluation. Results: No significant differences were found in anastomotic complications. The colonic bursting pressures in the KRG groups were statistically significantly better than in the control groups. The hydroxyproline content was also significantly higher in Group C than in Group A. Histological examination confirmed that KRG treatment significantly increased neovascularization, fibroblastic activity and collagen content compared with controls on POD 7. Discussion: Peri-operative administration of the KRG has a positive influence on the healing of colonic anastomosis in rats.en_US
dc.identifier.doi10.4328/ACAM.21112
dc.identifier.endpage769en_US
dc.identifier.issn2667-663X
dc.identifier.issue7en_US
dc.identifier.startpage765en_US
dc.identifier.urihttps://doi.org/10.4328/ACAM.21112
dc.identifier.urihttps://hdl.handle.net/11468/19767
dc.identifier.volume13en_US
dc.identifier.wosWOS:000827277300012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKorean Red Ginsengen_US
dc.subjectColonen_US
dc.subjectAnastomosisen_US
dc.titleEffect of korean red ginseng on colon anastomotic healing: A randomised controlled experimental studyen_US
dc.titleEffect of korean red ginseng on colon anastomotic healing: A randomised controlled experimental study
dc.typeArticleen_US

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