Evaluation of serum ghrelin levels in patients with vitiligo

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dc.contributor.authorDemir B.
dc.contributor.authorUçak H.
dc.contributor.authorÇiçek D.
dc.contributor.authorErden I.
dc.contributor.authorDertlio?lu S.
dc.contributor.authorAydin S.
dc.contributor.authorHalisdemir N.
dc.date.accessioned2024-04-24T17:58:23Z
dc.date.available2024-04-24T17:58:23Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: There are several publications about vitiligo being related to metabolic disturbances such as insulin resistance, lipid abnormalities, and metabolic syndrome. Plasma ghrelin levels were found to be low in obese patients and it is accepted to be one of important findings of metabolic syndrome such as hyperinsulinemia and insulin resistance. The current study aimed to investigate change in serum ghrelin levels in patients with vitiligo. Material and Methods: A total of 30 patients presenting with vitiligo and 30 control subjects participated in this study. Fasting blood glucose, serum lipids, insulin, C-peptide and thyroid function tests were measured. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate insulin resistance. Ghrelin levels were determined by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's protocol. Results: The mean serum ghrelin levels in the vitiligo patient group was 45.27±16.12 pg/mL and was statistically significantly higher in the control group 35.89±19.37 pg/mL, (p=0.04). The mean serum ghrelin level in the patients with insulin resistance 31.65±16.69 pg/mL was compared to the patient without insulin resistance 43.55±17.99 pg/mL and found statistically significant lower (p=0.02). Conclusion: In conclusion, the researchers found that ghrelin levels in patients with vitiligo were significantly high compared with controls and the researchers could not correlate this condition with serum glucose levels and body mass index. This increase in serum ghrelin levels in patients with vitiligo might be related to oxidative stress. Copyright © 2014 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/dermato.2014-41650
dc.identifier.endpage98en_US
dc.identifier.issn1300-0330
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84921927125
dc.identifier.scopusqualityQ4
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.5336/dermato.2014-41650
dc.identifier.urihttps://hdl.handle.net/11468/23889
dc.identifier.volume24en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherOrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S.en_US
dc.relation.ispartofTurkiye Klinikleri Dermatoloji
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGhrelinen_US
dc.subjectInsulin Resistanceen_US
dc.subjectVitiligoen_US
dc.titleEvaluation of serum ghrelin levels in patients with vitiligoen_US
dc.titleEvaluation of serum ghrelin levels in patients with vitiligo
dc.title.alternativeVitiligolu hastalarda serum grelin seviyesinin de?erlendirilmesien_US
dc.title.alternativeVitiligolu hastalarda serum grelin seviyesinin de?erlendirilmesi
dc.typeArticleen_US

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