The effects of allopurinol on stomach mucosal barrier of rats subjected to ischemia-reperfusion

Basit Öğe Kaydı
dc.contributor.authorKurt, Doğan
dc.contributor.authorGüzel, Cihat
dc.contributor.authorKanay, Zeki
dc.contributor.authorCeylan, Kader
dc.contributor.authorÖnen, Abdurrahman
dc.date.accessioned2024-04-24T18:56:52Z
dc.date.available2024-04-24T18:56:52Z
dc.date.issued2000
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe present experimental study was carried out on rats subjected to ischemia and reperfusion. The effects of allopurinol on mucus, an important component of the stomach mucosal barrier, were investigated. Twenty-one Swiss Albino rats, each weighing 200-250 g, were used. On the control group, no treatment was performed, while the sham operation group was subjected to 30 minutes of ischemia and 20 minutes of reperfusion. Then, stomachs were examined for ulcerative lesions, and ulcer scores were recorded. Mucus content was determined by the Corne method. In the sham group, the mucus decreased to a significant extent (p<0.01). It was observed that allopurinol prevented stomach lesions (p<0.01). Also, allopurinol prevented mucus reduction in rats subjected to ischemia and reperfusion (p<0.01). The results indicate that allopurinol is effective on stomach mucosal barrier parameters and in preventing stomach lesions caused by ischemia and reperfusion.en_US
dc.identifier.endpage451en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.startpage449en_US
dc.identifier.trdizinid12703
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/12703
dc.identifier.urihttps://hdl.handle.net/11468/25535
dc.identifier.volume30en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe effects of allopurinol on stomach mucosal barrier of rats subjected to ischemia-reperfusionen_US
dc.titleThe effects of allopurinol on stomach mucosal barrier of rats subjected to ischemia-reperfusion
dc.typeOtheren_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu