Differential effect of glutathione depletion on glycogenolysis in isolated rat hepatocytes mediated by alpha-adrenoceptor agonists and glucagon

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dc.contributor.authorAtmaca, Mukadder
dc.contributor.authorFry, Jeffrey R.
dc.date.accessioned2024-04-24T18:58:51Z
dc.date.available2024-04-24T18:58:51Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractGlutathione (GSH) exerts a variety of cytoprotecive effects, but is readily depleted from cells under a variety of stressful stimuli. The impact of GSH depletion on receptor-mediated activity in rat hepatocytes has been studied with regard to glycogenolysis stimulated with a-adrenoceptor agonists or glucagon, which exert their actions through different signalling pathways. Depletion of GSH content (70%) by diethyl maleate had no effect on the redox status of the cells or on basal or glucagon-stimulated glycogenolysis, but significantly reduced the response to the a-adrenoceptor agonists adrenalin and phenylephrine. These results highlight the possible modulatory effects of GSH on receptor-mediated activity in hepatocytes.en_US
dc.identifier.endpage74en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.startpage71en_US
dc.identifier.trdizinid45525
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/45525
dc.identifier.urihttps://hdl.handle.net/11468/26046
dc.identifier.volume35en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleDifferential effect of glutathione depletion on glycogenolysis in isolated rat hepatocytes mediated by alpha-adrenoceptor agonists and glucagonen_US
dc.titleDifferential effect of glutathione depletion on glycogenolysis in isolated rat hepatocytes mediated by alpha-adrenoceptor agonists and glucagon
dc.typeArticleen_US

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