Phenotypical examination of the macrolide-lincosamide-streptogramin B resistance in Staphylococcus isolates

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dc.contributor.authorOzbek, Erdal
dc.contributor.authorTemiz, Hakan
dc.contributor.authorTekay, Fikret
dc.contributor.authorKalayci, Raike
dc.contributor.authorAkkoc, Hasan
dc.date.accessioned2024-04-24T17:28:08Z
dc.date.available2024-04-24T17:28:08Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of the present study was to evaluate the phenotypic characteristics of the macrolide-lincosamide-streptogramin B (MLSB) resistance in Staphylococcus aureus and coagulase-negative staphylococci (CNS) strains isolated from various clinical samples in our hospital. The study was conducted on 516 Staphylococcus isolates isolated from various clinical samples in Microbiology Laboratory of Diyarbakir State Hospital between January, 2009 and December, 2009. After the identification of microorganisms via conventional methods and the evaluation of their methicillin resistance profile, disk approximation test was performed using erythromycin (15 mu g) and clindamycin (2 mu g) disks in order to determine MLSB resistance phenotypes. Of 516 Staphylococcus isolates, 208 were determined to be S. aureus and 308 were CNS. The MLSB resistance of isolates was 56.2%, whereas the resistance due to the efflux pump was determined to be 3.5%. The MLSB resistance phenotype was determined in 38% of S. aureus strains and 68.5% of CNS strains. The presence of MLSB resistance was determined to be higher in methicillin-resistant group (74.7%) compared to the methicillin-susceptible group (23.9%). While constitutive MLSB resistance (cMLS(B)) and inducible MLSB resistance (iMLS(B)) were determined in 48.9 and 19.1% of methicillin-resistant S. aureus strains, respectively, these rates were 2.6 and 10.5% for methicillin-susceptible strains, respectively. The rate of constitutive resistance was determined to be 41.5% in methicillin resistant CNS, whereas the rate of inducible resistance was determined to be 35.9%. In methicillin-susceptible CNS group, cMLS(B) and iMLS(B) resistances were determined to be 17.6 and 23%, respectively. The cMLS(B) phenotype was more common among methicillin-resistant S. aureus and CNS group, whereas iMLS(B) phenotype was more common among methicillin-susceptible S. aureus strains. In conclusion, we suggest that the determination and reporting of the presence of inducible resistance is of great importance regarding the success of therapy; therefore, it would be beneficial to use D test in routine antibiogram studies.en_US
dc.identifier.doi10.5897/AJMR12.159
dc.identifier.endpage3296en_US
dc.identifier.issn1996-0808
dc.identifier.issue13en_US
dc.identifier.startpage3292en_US
dc.identifier.urihttps://doi.org/10.5897/AJMR12.159
dc.identifier.urihttps://hdl.handle.net/11468/20343
dc.identifier.volume6en_US
dc.identifier.wosWOS:000303813500029
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal of Microbiology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStaphylococcus Aureusen_US
dc.subjectCoagulase-Negative Staphylococcien_US
dc.subjectMacrolide-Lincosamide-Streptogramin Ben_US
dc.titlePhenotypical examination of the macrolide-lincosamide-streptogramin B resistance in Staphylococcus isolatesen_US
dc.titlePhenotypical examination of the macrolide-lincosamide-streptogramin B resistance in Staphylococcus isolates
dc.typeArticleen_US

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