Adenosine deaminase gene G22a polymorphism as a risk factor for schizophrenia in Turkish population

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dc.authorid33449en_US
dc.authorid203292en_US
dc.authorid156312en_US
dc.authorid53818en_US
dc.authorid0000-0001-7639-1122en_US
dc.contributor.authorRüstemoğlu, Aydın
dc.contributor.authorCumurcu, Birgül Elbozan
dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorBalkan, Mahmut
dc.contributor.authorYiğit, Serbülent
dc.contributor.authorUzun, Melike
dc.date.accessioned2020-03-10T12:52:35Z
dc.date.available2020-03-10T12:52:35Z
dc.date.issued2016
dc.departmentDepartment of Medical Biology, Faculty of Medicine, Dicle Universityen_US
dc.description.abstractObjective: The aim of this study was to investigate whether the G22A polymorphism of adenosine deaminase (ADA) gene is associated with schizophrenia in Turkish population. Methods: In this study, we evaluated 113 patients with schizophrenia and 121 individuals without the disease. The ADA G22A polymorphism was examined using allele specific-polymerase chain reaction (PCR). Results: The ADA G22A genotype frequencies of GG, GA, and AA were 79.3% (96/121), 20.7% (25/121) and 0% (0) in the control group, while 87.6 % (99/113), 10.6% (12/113), 1.8% (2/113) in the patient group, respectively. There was a statistically significant difference in genotype distribution between patients and controls (p=0.017). Also the frequency of GA genotype was found significantly lower in patients compared with healthy controls (OR = 0.46, 95% Cl 0.22-0.96, p =0.048). However, there was not any noticeable difference in allele distribution between the groups (p>0.05). In addition, the frequency of GG genotype in the male patient group significantly higher, and GA genotype significantly lower compared to the male control group, were found (p=0.036, p=0.005, respectively). No association was found for the female group. Conclusion: Our results show that, the G22A polymorphism of ADA gene may be associated with schizophrenia in Turkish population. The ADA GA genotype is likely to reduce, whereas GG genotype increased genetic susceptibility to schizophrenia, especially in males. Further studies should be repeated with different study subjects and/or other ethnic subjects to generalize the conclusion of this study.en_US
dc.identifier.citationRüstemoğlu, A., Cumurcu, B.E., Nursal, A.F., Balkan, M., Uzun, M., ve Yiğit, S. (2016). Adenosine deaminase gene G22a polymorphism as a risk factor for schizophrenia in Turkish population. Dicle Tıp Dergisi, 43(2), 218-223.en_US
dc.identifier.doi10.5798/diclemedj.0921.2016.02.0670en_US
dc.identifier.endpage223en_US
dc.identifier.issn1300-2945
dc.identifier.issn1308-9889
dc.identifier.issue2en_US
dc.identifier.startpage218en_US
dc.identifier.urihttps://hdl.handle.net/11468/4811
dc.identifier.urihttp://www.diclemedj.org/upload/sayi/60/Dicle%20Med%20J-02956.pdf
dc.identifier.volume43en_US
dc.institutionauthor0-Belirlenecek
dc.language.isoenen_US
dc.publisherDicle Üniversitesi Tıp Fakültesien_US
dc.relation.ispartofDicle Tıp Dergisien_US
dc.relation.publicationcategory0-Belirleneceken_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectSchizophreniaen_US
dc.subjectADA geneen_US
dc.subjectG22A polymorphismen_US
dc.subjectŞizofrenien_US
dc.subjectADA genien_US
dc.subjectG22A polimorfizmien_US
dc.titleAdenosine deaminase gene G22a polymorphism as a risk factor for schizophrenia in Turkish populationen_US
dc.title.alternativeTürk populasyonunda şizofreni hastalığı için bir risk faktörü olarak adenozin deaminaz geni G22a polimorfizmien_US
dc.typeArticleen_US

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