Anticancer Activities of Zinc Oxide Nanoparticles (ZnONPs) Synthesized from Mentha longifolia L. Leaf Extract

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dc.contributor.authorİpek, Polat
dc.contributor.authorBaran, Mehmet Fırat
dc.contributor.authorHatipoğlu, Abdulkerim
dc.contributor.authorBaran, Ayşe
dc.date.accessioned2025-03-08T18:28:55Z
dc.date.available2025-03-08T18:28:55Z
dc.date.issued2024
dc.departmentDicle Üniversitesi
dc.description.abstractRecently, there has been a remarkable increase in cancer and cancer-related deaths. In this study, the impacts of zinc oxide nanoparticles (ZnONPs) produced from the aqueous leaf extract of Mentha longifolia L. (ML) on ovary adenocarcinoma (OVCAR-3), colorectal carcinoma (HCT-116), and healthy retinal pigment epithelial cell (RPE-1) lines were investigated. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) test was performed to discover its antiproliferative properties. As a result of the application of ML-ZnONPs on RPE-1, OVCAR-3, and HCT-116 cell lines at doses (µg/mL) of 250, 500, and 1000 for 24 hours, the viability rates (%) in the cell lines were 18.73-30.56, 21.98-28.76, and 27.27-40.93, respectively. In the 48-hour application, the viability rates (%) of the same cells were between 29.51-46.83, 32.49-40.81, and 46.82-44.37, respectively. The MTT test revealed that ML-ZnONPs strongly suppressed the growth of RPE-1, OVCAR-3, and HCT-116 cell lines. The test showed that the effect of dose increase and time on the viability of both cancer cell lines was negative.
dc.identifier.doi10.21597/jist.1357481
dc.identifier.endpage114
dc.identifier.issn2536-4618
dc.identifier.issue1
dc.identifier.startpage107
dc.identifier.urihttps://doi.org/10.21597/jist.1357481
dc.identifier.urihttps://hdl.handle.net/11468/31530
dc.identifier.volume14
dc.language.isoen
dc.publisherIğdır Üniversitesi
dc.relation.ispartofJournal of the Institute of Science and Technology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_21250205
dc.subjectCytotoxic potential
dc.subjectMentha longifolia L.
dc.subjectZinc oxide nanoparticles
dc.subjectMTT
dc.subjectHCT-116
dc.subjectOVCAR-3
dc.titleAnticancer Activities of Zinc Oxide Nanoparticles (ZnONPs) Synthesized from Mentha longifolia L. Leaf Extract
dc.typeArticle

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