Synthesis of imine group containing chiral BIS (Phosphinite) ligands and Ru(II) complexes: Investigation of their catalytic activity in the asymmetric transfer hydrogenation of ketones

Basit Öğe Kaydı
dc.contributor.advisorDurap, Feyyaz
dc.contributor.authorSaleh, Najmuldain Abdullah
dc.date.accessioned2016-03-29T07:22:28Z
dc.date.available2016-03-29T07:22:28Z
dc.date.issued2016
dc.date.submitted2015
dc.departmentDicle Üniversitesi, Fen Bilimleri Enstitüsü, Kimya Anabilim Dalıen_US
dc.description.abstractTransfer hydrogenation processes are attracting considerable attention in synthetic chemistry due to their operational simplicity. Asymmetric transfer hydrogenation of simple ketones by using chiral catalysts is one of the most significant ways to obtain chiral alcohols in organic synthesis. The most popular ligands employed in asymmetric catalysis are phosphorus containing ones. The common feature of the ligands used for this purpose is to have a C2 symmetry axis. Although there have been many reports on these type ligands and their transition metal complexes, to the best of our knowledge, there are few studies on imine containing bis(phosphinites) and their catalytic activity in asymmetric transfer hydrogenation. In the present study, firstly, 1-({[(1R,2R)-2-{[(2-hydroxynaphthalen-1-yl)methylidene] amino}cyclohexyl]imino}methyl)naphthalen-2-ol was prepared as precursors for phosphinites according to a literature procedure. Then, new chiral C2-symmetric bis(phosphinite) ligands were synthesized the corresponding 1-({[(1R,2R)-2-{[(2-hydroxynaphthalen-1- yl)methylidene]amino}cyclohexyl] imino} methyl)naphthalen-2-ol and two equivalents of (Cy)2PCl, PPh2Cl or P(i-Pr)2Cl in high yields. Ru(II) metal complexes of the chiral phosphinite ligands were synthesized by treating of [Ru(?6 -p-cymene)(?-Cl)Cl]2 with the phosphinites in 1:1 molar ratio in CH2Cl2 and their catalytic activity in asymmetric transfer hydrogenation were investigated in the reaction of acetophenone derivatives with isopropyl alcohol. Keywords: Asymmetric transfer hydrogenation, Phosphinite, Catalysis, Ruthenium, Chirality
dc.description.sponsorshipBu tez (Project no: 14-FF-l37) Proje numarasıyla DÜBAP tarafından desteklenmiştir.en_US
dc.identifier.urihttps://hdl.handle.net/11468/1771
dc.institutionauthorSaleh, Najmuldain Abdullah
dc.language.isoenen_US
dc.relation.publicationcategoryTezen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAsymmetric transfer hydrogenationen_US
dc.subjectPhosphiniteen_US
dc.subjectCatalysisen_US
dc.subjectCatalysisen_US
dc.subjectRutheniumen_US
dc.subjectChiralityen_US
dc.titleSynthesis of imine group containing chiral BIS (Phosphinite) ligands and Ru(II) complexes: Investigation of their catalytic activity in the asymmetric transfer hydrogenation of ketonesen_US
dc.typeMaster Thesisen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
Ä°sim:
Synthesis of imine group containing chiral bis(phosphinite) ligands and ru(ii) complexes Investigation of their catalytic activity in the asymmetric transfer hydrogenation of ketones.pdf
Boyut:
1.15 MB
Biçim:
Adobe Portable Document Format
Ä°ndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
Ä°sim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
Ä°ndir

Koleksiyon

Fen Bilimleri Enstitüsü Tezler