Evaluation of metabolic parameters of microsatellites stable and instable colorectal cancer patients via PET/CT

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dc.contributor.authorTuzcu, Şadiye Altun
dc.contributor.authorÇetin, İlbey Erkin
dc.contributor.authorGüzel, Fatih
dc.contributor.authorÇetinkaya, Erdal
dc.contributor.authorTaşdemir, Bekir
dc.contributor.authorBüyükbayram, Hüseyin
dc.date.accessioned2025-02-22T14:13:29Z
dc.date.available2025-02-22T14:13:29Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractAims: Microsatellite instability has been determined as an important indicator in selecting chemotherapy drugs in colorectal cancer. Within the scope of this research, we aimed to elucidate the pathology reports and determine whether the metabolic parameters detected by PET/CT differ in MSI-positive and negative patients. Methods: A total of 35 patients were analyzed retrospectively. The patient population consisted of patients who applied to the Nuclear Medicine Department with a diagnosis of colon or rectum cancer, underwent PET/CT imaging for staging purposes, and were operated on. Results: A total of 35 colon or rectum cancer patients were included in this retrospective analysis. When microsatellite instability was analyzed among the patients, it was found that female patients comprised 4 microsatellite instability-positive and 16 microsatellite instability-negative individuals. On the other hand, 5 of the males were microsatellite instability positive, and 10 were microsatellite instability negative. The mean SUVmax value was 16.4±8.2, SUVmean was 8.1±1.9, TLG was 392.4±520.8, and MTV was 26.5±25.4 in the microsatellite instability-positive individuals. On the other hand, the mean SUVmax value was 22.7±9.7, SUVmean was 5.2±2.2, TLG was 316.4±325.7, and MTV was 21.7±21.7 in the microsatellite instability-negative individuals. Conclusion: With the advancement of image analysis technology, MTV, and TLG, volumetric indexes derived from 18F-FDG PET have been proposed for risk stratification of cancer patients. Regarding the outcomes of this research, the semiquantitative and metabolic parameters obtained by PET/CT are not different in colorectal cancer cases with instable and stable microsatellites.en_US
dc.identifier.doi10.47582/jompac.1462904
dc.identifier.endpage128en_US
dc.identifier.issn2717-7505
dc.identifier.issue2en_US
dc.identifier.startpage124en_US
dc.identifier.trdizinid1243033en_US
dc.identifier.urihttps://doi.org/10.47582/jompac.1462904
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1243033
dc.identifier.urihttps://hdl.handle.net/11468/30016
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofJournal of medicine and palliative care (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_TR_20250222
dc.subjectColorectal canceren_US
dc.subjectmicrosatellite instabilityen_US
dc.subjectPositron Emission Tomography/Computed Tomography (PET/CT)en_US
dc.subjectmismatch repair genes (MMR)en_US
dc.subjectstandardized uptake value (SUV)en_US
dc.titleEvaluation of metabolic parameters of microsatellites stable and instable colorectal cancer patients via PET/CTen_US
dc.typeArticleen_US

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