The effects of flutamide on lipid profile, insulin sensitivity, hirsutism and gonadotrophins in women with polycystic ovary syndrome

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dc.contributor.authorBahceci M.
dc.contributor.authorTuzcu A.
dc.contributor.authorDursun M.
dc.contributor.authorErtem M.
dc.contributor.authorYukselen V.
dc.date.accessioned2024-04-24T18:44:01Z
dc.date.available2024-04-24T18:44:01Z
dc.date.issued1999
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, we evaluated metabolic changes and the effects of flutamide in 22 women with PCOS. Flutamide was administered for a 6-month period in a dose of 750 mg/day. The basal and after treatment body mass index, waist: hip ratio, blood glucose, insulin, lipids, Ferriman-Gallwey scoring (FGS), gonadotrophins, testosterone, trasaminazed and glucose: insulin (G:I) ratio were measured. For comparison, ANOVA was used. The sixth month mean FGS was significantly lower than the basal values (18.5±7.4 and 12.5±4.5, P<0.01). The mean basal G:I ratio was 3.31±1.12 and 6.21±2.53 at the sixth month. The sixth month G:I ratio was significantly higher (P<0.001). The total and LDL-cholesterol were decreased by flutamide (from 144±23 to 123±23 and from 88±32 to 60±25 mg/dl respectively. P<0.02 and P<0.01), whereas, the HDL-cholesterol level was increased with flutamide (from 44.8±3.9 to 46.5±3.2 mg/dl and P<0.001). LH (from 14.7±6.7 to 8.4±3 mlU/ml), LH/FSH ratio (from 3.4±1.7 to 1.9±0.6), total testosterone (from 0.87±0.29 to 0.61±0.18 ng/ml) and free testosterone (from 4.29±1.18 to 2.14±0.9 pg/ml) were decreased by flutamide (P<0.05). Thus, we reached three conclusions: 1-Flutamide may improve insulin insensitivity. 2-In PCOS, flutamide decreases total and LDL-cholesterol, and increases HDL-cholesterol. 3-Flutamide may improve the LH/FSH ratio and induce a decrease in testosterone.en_US
dc.identifier.endpage681en_US
dc.identifier.issn1300-0144
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-0032695602
dc.identifier.scopusqualityQ1
dc.identifier.startpage677en_US
dc.identifier.urihttps://hdl.handle.net/11468/24518
dc.identifier.volume29en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFlutamideen_US
dc.subjectHirsutism And Lipidsen_US
dc.subjectInsulin Sensitivityen_US
dc.subjectPcosen_US
dc.titleThe effects of flutamide on lipid profile, insulin sensitivity, hirsutism and gonadotrophins in women with polycystic ovary syndromeen_US
dc.titleThe effects of flutamide on lipid profile, insulin sensitivity, hirsutism and gonadotrophins in women with polycystic ovary syndrome
dc.typeArticleen_US

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