Oxidative stress in marasmic children: Relationships with leptin

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dc.contributor.authorBoşnak, Mehmet
dc.contributor.authorKelekçi, Selvi
dc.contributor.authorYel, Servet
dc.contributor.authorKoçyi?it, Yüksel
dc.contributor.authorŞen, Velat
dc.contributor.authorEce, Aydın
dc.date.accessioned2024-04-24T17:58:14Z
dc.date.available2024-04-24T17:58:14Z
dc.date.issued2010
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractAim: We aimed to investigate the levels and relationships of antioxidants, lipid peroxidation and leptin altogether in marasmic malnutrition. Method: Thirty marasmic children (age 14.4±10.3 months) and 28 control subjects were included. Erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities, glutathione (GSH) level, and serum malondialdehyde (MDA) and leptin levels were measured. Result: Malnourished children had significantly lower erythrocyte SOD activity (1583±417 vs. 3403±1901 U/gHb, respectively, P<0.001), CAT activity (1139±92 vs. 1663±302 k/gHb, p<0.001), GSH level (25.9±5.4 vs. 48.1±17.0 ?mol/gHb, p<0.001) and leptin levels (3.6±1.1 vs. 11.8±4.5 ng/mL, respectively, p<0.001), compared with control subjects. However mean MDA concentration of marasmic children (11.1±2.5 nmol/mL) was found to be significantly higher than that of the control subjects (6.6±3.9 nmol/mL) (p<0.001). Significant negative correlations were detected between CAT and MDA (r=-0.476, P=0.009), between SOD and MDA (r=-0.534, p=0.004), and GSH and MDA (r=-0.439, p=0.015) in marasmic children. No significant correlation was found between leptin and oxidation markers (p>0.05). Conclusion: Marasmic children had increased lipid peroxidation and decreased antioxidant enzyme activities and leptin. Lack of associations between leptin, anthropometric measurements and oxidative stress may be due to the excessive loss of adipose tissue and related very low levels of leptin in marasmic children.en_US
dc.identifier.citationBoşnak, M., Kelekçi, S., Yel, S., Koçyiǧit, Y., Şen, V. ve Ece, A. (2010). Oxidative stress in marasmic children: Relationships with leptin. European Journal of General Medicine, 7(1), 1-8.
dc.identifier.doi10.29333/ejgm/82786
dc.identifier.endpage8en_US
dc.identifier.issn1304-3889
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-78650285625
dc.identifier.scopusqualityN/A
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.29333/ejgm/82786
dc.identifier.urihttps://hdl.handle.net/11468/23742
dc.identifier.volume7en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTıp Araştırmaları Derneğien_US
dc.relation.ispartofEuropean Journal of General Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCatalaseen_US
dc.subjectGlutathioneen_US
dc.subjectLeptinen_US
dc.subjectLipid peroxidationen_US
dc.subjectMalnutritionen_US
dc.subjectSuperoxide dismutaseen_US
dc.titleOxidative stress in marasmic children: Relationships with leptinen_US
dc.titleOxidative stress in marasmic children: Relationships with leptin
dc.typeArticleen_US

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