Molecular epidemiology of HIV-1 strains in the south-east and east of Turkey

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dc.contributor.authorÇelen, Mustafa Kemal
dc.contributor.authorSayan, Murat
dc.contributor.authorDal, Tuba
dc.contributor.authorAyaz, Celal
dc.contributor.authorTekin, Alicem
dc.contributor.authorÖzekinci, Tuncer
dc.contributor.authorKoruk, Sude Tekin
dc.contributor.orcid0000-0002-4374-7193
dc.contributor.orcid0000-0001-5876-2241
dc.date.accessioned2024-04-24T17:56:06Z
dc.date.available2024-04-24T17:56:06Z
dc.date.issued2015
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: To detect the subtype characterization and drug-resistant mutations in HIV-1 strains after the refugee movement from Syria to Turkey between 2011 and 2014 in south east border lines. METHODS: A total of 65 patients were included in this study, of which 57 (88%) patients were antiretroviral therapy-naive patients. HIV-1 RNA was detected and quantified by real-time PCR assay. HIV-1 subtypes and circulating recombinant forms (CRFs) were identified by phylogenetic analysis (neighbor-joining method), and drug-resistant mutations were analyzed. RESULTS: Three major HIV groups were indicated. Two of these groups were located in subtype B. The other group showed heterogeneity. Subtype B (48/65, 73.8%), followed by CRFs (12/65, 18.5%) was the most common strain. Subtype of CRFs consisted of CRF01_AE (9/65, 13.8%) and CRF02_AG (3/65, 4.6%). Subtype C (1/65, 1.5%), sub-subtypes A1 (2/65, 3.1%) and F1 (2/65, 3.1%) were also detected with low prevalence. The rate of overall primary antiretroviral resistance was 4.9% (3/61). Drug-resistant rate for non-nucleoside reverse transcriptase inhibitors was 4.9%. The thymidine analogue mutation rate was 13.1% (8/61). CONCLUSIONS: HIV molecular epidemiology studies are necessary to determine transmission patterns and spread. Subtype B and CRF01_AE, CRF02_AG are the most prevalent strains in the south-east of Turkey. However, subtype C, sub-subtypes A1 and F1 are of low prevalence but persist in the south-east of Turkey. In the near future, changing of HIV epidemiology will be possible in Turkey due to migration movement in border lines and resistance testing will play an important role in HIV management. © 2015 Hainan Medical University.en_US
dc.description.sponsorship13-TF-91en_US
dc.description.sponsorshipFoundation Project: Supported by Dicle University Medical Faculty (Grant No. 13-TF-91 ).en_US
dc.identifier.citationÇelen, M. K., Sayan, M., Dal, T., Ayaz, C., Tekin, A., Özekinci, T. ve diğerleri. (2015). Molecular epidemiology of HIV-1 strains in the south-east and east of Turkey. Asian Pacific Journal of Tropical Biomedicine, 5(9), 773-777.
dc.identifier.doi10.1016/j.apjtb.2015.07.009
dc.identifier.endpage777en_US
dc.identifier.issn2221-1691
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-84955171825en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage773en_US
dc.identifier.urihttps://doi.org/10.1016/j.apjtb.2015.07.009
dc.identifier.urihttps://hdl.handle.net/11468/23289
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S222116911500146X?via%3Dihub
dc.identifier.volume5en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHainan Medical Universityen_US
dc.relation.ispartofAsian Pacific Journal of Tropical Biomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHıv-1en_US
dc.subjectMolecular epidemiologyen_US
dc.subjectRefugee movementen_US
dc.subjectTurkeyen_US
dc.titleMolecular epidemiology of HIV-1 strains in the south-east and east of Turkeyen_US
dc.typeArticleen_US

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