Late Histopathological Features of Testis Tissue in a Patient With Male Pseudohermaphroditism Due to Leydig Cell Aplasia

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dc.contributor.authorBahceci, Selen
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorBahceci, Mithat
dc.contributor.authorTuzcu, Alpaslan
dc.contributor.authorGokalp, Deniz
dc.date.accessioned2024-04-24T17:40:18Z
dc.date.available2024-04-24T17:40:18Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractLeydig cell aplasia is a rare form of male pseudohermaphroditism. We determined Leydig cell aplasia in a 39 yr old patient, grown up as a female, with female external genitalia and primary amenorrhea. Gonads were bilaterally palpable in the inguinal regions. Karyotype was 46, XY. Hormonal evaluation revealed markedly elevated gonadotropin levels with a low testosterone, which failed to increase after human chorionic gonadotropin stimulation. In Leydig cell aplasia, classically, testicular histology reveals seminiferous tubules, whereas Leydig cells are not present or appear only as immature forms. In addition to classical features of Leydig cell aplasia, we determined diffuse fibrosis, atrophy, interstitial edema and marked thickness in lamina propria of seminiferous tubules, and although Sertoli cells were seen, no germ cell was present. Very long duration of undescended testes (cryptorchidism) may be responsible for these additional histopathological changes. Becasue of a criptorchid testis is more likley to undergo malignant degeneration than normal testes, many urologists recommend orchiectomy for unilaterally undescended testicle.en_US
dc.identifier.endpage28en_US
dc.identifier.issn1301-2193
dc.identifier.issue1en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://hdl.handle.net/11468/21732
dc.identifier.volume10en_US
dc.identifier.wosWOS:000217277200005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Endocrinology and Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeydig Cell Aplasiaen_US
dc.subjectMale Pseudohermaphroditismen_US
dc.subjectCryptorchidismen_US
dc.subjectDiffuse Fibrosisen_US
dc.subjectAtrophy And Interstitial Edemaen_US
dc.titleLate Histopathological Features of Testis Tissue in a Patient With Male Pseudohermaphroditism Due to Leydig Cell Aplasiaen_US
dc.titleLate Histopathological Features of Testis Tissue in a Patient With Male Pseudohermaphroditism Due to Leydig Cell Aplasia
dc.typeArticleen_US

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