SERUM PROLIDASE ENZYME ACTIVITY AND OXIDATIVE STATUS IN PATIENTS WITH SCLERODERMA

Basit Öğe Kaydı
dc.contributor.authorBozkurt, Mehtap
dc.contributor.authorDag, Evin
dc.contributor.authorOktayoglu, Pelin
dc.contributor.authorEm, Serda
dc.contributor.authorYuksel, Hatice
dc.contributor.authorCaglayan, Mehmet
dc.contributor.authorSariyildiz, Mustafa Akif
dc.date.accessioned2024-04-24T17:44:24Z
dc.date.available2024-04-24T17:44:24Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To assess serum prolidase enzyme activity and oxidative stress in patients with scleroderma (also known as systemic sclerosis, or SSc) and determine its relationship with serum oxidative status. Methods: The study population consisted of SSc patients (n = 21) and healthy participants (n =29). Serum prolidase enzyme activity, total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (051), and paraoxonase-1 (PON-1) levels were compared betweeen the two groups. Results: The mean duration of SSc involvement was 5 years; and the mean modified Rodnan skin score was 16. No statistically significant differences existed between the SSc groups and the control participants in terms of age, gender, TAS, PON-I, and haematocrit levels. Serum prolidase activity, 051, and TOS levels were statistically significantly higher in SSc patients in comparison with controls participants. Also serum prolidase activity was statistically higher in Raynaud's phenomenon positive patients than Raynaud's phenomenon negative patients. But no correlation emerged between the serum prolidase activity and modified Rodnan Skin Score (P=0.235, r=0.304). Conclusion: High prolidase activity may indicate critical biological activities relevant to pathological events in SSc, and this activity may be a biological indicator of disease. Further studies are needed to verify these findings.en_US
dc.identifier.endpage132en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue1en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://hdl.handle.net/11468/22021
dc.identifier.volume30en_US
dc.identifier.wosWOS:000335937700020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone Marrow Mesenchymal Stem Cellsen_US
dc.subjectMouseen_US
dc.subjectCultureen_US
dc.titleSERUM PROLIDASE ENZYME ACTIVITY AND OXIDATIVE STATUS IN PATIENTS WITH SCLERODERMAen_US
dc.titleSERUM PROLIDASE ENZYME ACTIVITY AND OXIDATIVE STATUS IN PATIENTS WITH SCLERODERMA
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu