Bioguided Isolation of Secondary Metabolites fromSalvia cerino-pruinosa Rech. f. var. cerino-pruinosa

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dc.contributor.authorKolak, Ufuk
dc.contributor.authorErtas, Abdulselam
dc.contributor.authorFirat, Mehmet
dc.contributor.authorCakirca, Hatice
dc.contributor.authorTopcu, Gulacti
dc.contributor.authorYener, Ismail
dc.contributor.authorAkdeniz, Mehmet
dc.date.accessioned2024-04-24T19:13:09Z
dc.date.available2024-04-24T19:13:09Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn the current study, the ethanol extracts prepared from the aerial parts and roots of an endemicspecies, Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa were fractionated on silica gel columns and testedfor determination of their antioxidant activity using DPPH free radical and ABTS cation radical scavenging, andcupric reducing antioxidant capacity (CUPRAC) test assays. Twenty known secondary metabolites were isolatedfrom the active antioxidant fractions; rosmarinic acid (1), chlorogenic acid (2), caffeic acid (3), 4- hydroxybenzoic acid (4), benzoic acid (5), luteolin 7-O-glucoside (6), bis-(2-ethylhexyl)benzene-1,2- dicarboxylate (7), salvianolic acid A (8), salvianolic acid B (9), 7-acetylroyleanone (10), 6,7-dehydroroyleanone(11), ferruginol (12), inuroyleanol (13), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (14), ursolic acid(15), oleanolic acid (16), taraxasterol (17), lupenone (18), ?-sitosterol (19), and stigmasterol (20). Rosmarinicacid, which was obtained from the aerial parts, was found to be the best antioxidant compound among theisolated secondary metabolites in DPPH free radical and ABTS cation radical scavenging, and CUPRAC assays(IC50: 1.20±0.04 ?g/mL, IC50: 1.74±0.06 ?g/mL, A0.5: 1.22±0.02 ?g/mL, respectively). Chlorogenic and caffeicacids, luteolin 7-O-glucoside, salvianolic acids A and B, and inuroyleanol exhibited also high antioxidantactivity in the mentioned assays.en_US
dc.identifier.endpage592en_US
dc.identifier.issn1307-6167
dc.identifier.issue6en_US
dc.identifier.startpage585en_US
dc.identifier.trdizinid464279
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/464279
dc.identifier.urihttps://hdl.handle.net/11468/28414
dc.identifier.volume15en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofRecords of Natural Products
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleBioguided Isolation of Secondary Metabolites fromSalvia cerino-pruinosa Rech. f. var. cerino-pruinosaen_US
dc.titleBioguided Isolation of Secondary Metabolites fromSalvia cerino-pruinosa Rech. f. var. cerino-pruinosa
dc.typeArticleen_US

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