Is there an association between immunohistochemical parameters of breast cancer and metabolic parameters obtained with 18F-fluorodeoxyglucose PET / CT?

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dc.contributor.authorTuzcu S.A.
dc.contributor.authorGezici A.
dc.contributor.authorTaşdemir B.
dc.contributor.authorKaplan İ.
dc.contributor.authorBüyükbayram H.
dc.contributor.authorÇetin F.A.
dc.date.accessioned2024-04-24T18:46:18Z
dc.date.available2024-04-24T18:46:18Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: The aim of our study to investigate relationship between 18F -fluorodeoxyglucose PET/CT (18F-FDG PET/CT) metabolic parameters and immunohistochemical factors in breast carcinomas. Material and method: Patients with breast carcinomas who underwent 18F-FDG PET/CT imaging at our department between May 2018 and November 2019 were included in this study. A total of 146 female patients were included (aged 49.1 ± 13.4years; range, 26-87 years). PET scanning was performed in 3D mode from the skull ceiling to the middle of the thigh. Metabolic parameters such as TLG (Total lesion glycolysis), MTV (Metabolic tumor volume), SUVmean and SUVmax values were calculated. We obtained the histopathological findings, including the size of invasive cancer, histological type, histological grade, ER and PR status, epidermal growth factor receptor (HER2) and Ki-67 of the primary tumor by reviewing the pathology reports. Result: SUV max and SUVmean of Oestrogen receptor negative group were statistically higher than Oestrogen receptor positive group (p=0.009). SUVmean of progesterone receptor negative group were statistically higher than progesterone receptor positive group (p=0.05). Ki-67 of the Oestrogen receptor negative group and progesterone receptor negative group were statistically higher than Oestrogen receptor and progesterone receptor positive group (p=0.001, 0,001 respectively). Both SUVmax and SUVmean of Ki-67 positive group were statistically higher than Ki-67negative group (p=0.0001). Conclusions: 1-SUV max, SUVmean and Ki-67 of Oestrogen receptor negative group were statistically higher than Oestrogen receptor positive group. 2-SUVmean and Ki-67 of progesterone receptor negative group were statistically higher than progesteron receptor positive group. 3-HER2 positive and/or triple negative breast cancers were not associated with 18F-FDG PET/CT metabolic parameters © 2019 Published by International Archives of Medical Research. All rights reserveden_US
dc.identifier.endpage61en_US
dc.identifier.issn1307-5624
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85149072541
dc.identifier.scopusqualityQ4
dc.identifier.startpage51en_US
dc.identifier.urihttps://hdl.handle.net/11468/25149
dc.identifier.volume11en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherDergiParken_US
dc.relation.ispartofInternational Electronic Journal of Geometry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject18f-Fdg Pet/Cten_US
dc.subjectBreast Canceren_US
dc.subjectOestrogen Receptoren_US
dc.titleIs there an association between immunohistochemical parameters of breast cancer and metabolic parameters obtained with 18F-fluorodeoxyglucose PET / CT?en_US
dc.titleIs there an association between immunohistochemical parameters of breast cancer and metabolic parameters obtained with 18F-fluorodeoxyglucose PET / CT?
dc.typeArticleen_US

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