Comparison of the Effect of Periodontal Therapy and Diode Decontamination and Periodontal Therapy Alone on the Amount of TNF-? in Systemically Healthy Chronic Periodontitis Patients A Non-Randomized Clinical Trial

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dc.contributor.authorDogru, Arzum Guler
dc.contributor.authorToprak, Omer
dc.contributor.authorUner, Devrim Deniz
dc.contributor.authorIzol, Bozan Serhat
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorDogru, Mehmet
dc.contributor.authorIpek, Fikret
dc.date.accessioned2024-04-24T17:48:06Z
dc.date.available2024-04-24T17:48:06Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To evaluate the outcome of initial periodontal therapy and additional diode laser decontamination therapy on clinical parameters and the amount of tumor necrosis factor alpha (TNF-alpha) in gingival crevicular fluid (GCF) in patients with chronic periodontitis. STUDY DESIGN: The study included 22 patients who were diagnosed with chronic periodontitis and who had at least 1 (>= 5 mm) periodontal pocket in the posterior region of each upper left hemi-arcade. The study was designed as a split-mouth study involving mechanical therapy on the right side and nonsurgical periodontal therapy plus diode laser decontamination therapy on the left side. RESULTS: A statistically significant decrease was observed in clinical parameters at 3 months when compared to the values at baseline in both treatment areas. The change in clinical parameters at 3 months after therapy was not significantly different between the groups (p>0.05). The comparison of GCF TNF-alpha levels at baseline and at 3 months in the 2 treatment areas identified significant changes in the TNF-alpha levels in the hemi-arcade treated with laser diode contamination therapy, whereas the changes in the hemi-arcade treated with nonsurgical periodontal therapy were not significant (p>0.05). A between-group comparison revealed no statistically significant difference at 3 months post-therapy, while the difference at 1 month was found to be statistically significant. CONCLUSION: The study found that laser therapy in addition to nonsurgical periodontal therapy has a positive effect on the clinical parameters and proinflammatory TNF-alpha levels in the early period but makes no contribution in the long term.en_US
dc.identifier.endpage188en_US
dc.identifier.issn0884-6812
dc.identifier.issue6en_US
dc.identifier.startpage180en_US
dc.identifier.urihttps://hdl.handle.net/11468/22886
dc.identifier.volume42en_US
dc.identifier.wosWOS:000619650600002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Periodontitisen_US
dc.subjectDental Plaqueen_US
dc.subjectDental Scalingen_US
dc.subjectDental Surgeryen_US
dc.subjectDiode Laseren_US
dc.subjectGingival Crevicular Fluiden_US
dc.subjectLasersen_US
dc.subjectNonsurgical Periodontal Therapyen_US
dc.subjectPeriodontal Attachment Lossen_US
dc.subjectPeriodontal Diseasesen_US
dc.subjectPeriodontal Pocketen_US
dc.subjectPeriodontitisen_US
dc.subjectTnf-Alphaen_US
dc.subjectTumor Necrosis Factor Alphaen_US
dc.titleComparison of the Effect of Periodontal Therapy and Diode Decontamination and Periodontal Therapy Alone on the Amount of TNF-? in Systemically Healthy Chronic Periodontitis Patients A Non-Randomized Clinical Trialen_US
dc.titleComparison of the Effect of Periodontal Therapy and Diode Decontamination and Periodontal Therapy Alone on the Amount of TNF-? in Systemically Healthy Chronic Periodontitis Patients A Non-Randomized Clinical Trial
dc.typeArticleen_US

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