Therapeutic Potential of Bacopa monnieri L. in Sciatic Nerve Ligation: Modulation of Regeneration and Oxidative Stress

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dc.contributor.authorAl-Yaqoobı, Ziadoon
dc.contributor.authorAltunlu, Öznur
dc.contributor.authorBurul, Feyza
dc.contributor.authorTopatan, Esma
dc.contributor.authorMokhtare, Behzad
dc.contributor.authorBudak Savaş, Ayşenur
dc.contributor.authorYörük, Mehmet Ali
dc.date.accessioned2025-02-22T14:13:29Z
dc.date.available2025-02-22T14:13:29Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractBacopa monnieri L. is a plant known for its neuroprotective properties with positive effects on neuronal regeneration and synaptic activity. In this study, the effects of Bacopa monnieri L. extract on the regeneration process in sciatic nerve injury, which is a peripheral nerve injury model, were investigated. Within the scope of this study, 18 Sprague–Dawley rats, each group containing six animals, were divided into three groups. Surgical ligation of the sciatic nerve was performed at the beginning of the experiment to induce sciatic nerve injury in the positive control and treatment groups. Following surgical intervention, the treatment group received a daily dose of 400 mg/kg extract for 15 days starting from the 14th day post surgery. The oxidative stress status in serum samples obtained from rats was investigated biochemically. Immunohistochemical measurements of tumor necrosis factor alpha and inducible nitric oxide synthase were also performed in the muscles surrounding the sciatic nerve. Upon examination of the results, it was observed that the treatment group exhibited a significant increase in antioxidant capacity compared to the control groups. Furthermore, the oxidant status in the treatment group was lower than that in the positive control group. Immunohistochemical examinations revealed an increase in tumor necrosis factor alpha- and inducible nitric oxide synthase immunoreactivity in the positive control group, while a decrease in the immunoreactivity of these inflammation markers was observed in the treatment group. In conclusion, Bacopa monnieri L. extract may contribute to recovery in peripheral nerve injury by regulating antioxidant and anti-inflammatory processes.en_US
dc.identifier.doi10.5152/JLASP.2023.23010
dc.identifier.endpage38en_US
dc.identifier.issn2791-8645
dc.identifier.issue2en_US
dc.identifier.startpage32en_US
dc.identifier.trdizinid1270961en_US
dc.identifier.urihttps://doi.org/10.5152/JLASP.2023.23010
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1270961
dc.identifier.urihttps://hdl.handle.net/11468/30011
dc.identifier.volume3en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofLaboratuvar Hayvanları Bilimi ve Uygulamaları dergisi (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_TR_20250222
dc.subjectAntioxidanten_US
dc.subjectperipheral nerve injuryen_US
dc.subjectİmmunohistokimyasalen_US
dc.subjectBacopa monnieri L.en_US
dc.subjectsciatic nerve ligationen_US
dc.titleTherapeutic Potential of Bacopa monnieri L. in Sciatic Nerve Ligation: Modulation of Regeneration and Oxidative Stressen_US
dc.typeArticleen_US

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