Association of Subclinical Hypothyroidism with Dyslipidemia and Increased Carotid Intima-Media Thickness in Children

Basit Öğe Kaydı
dc.contributor.authorDemir, Vasfiye
dc.contributor.authorYıldırım, Ruken
dc.contributor.authorHaspolat, Yusuf Kenan
dc.contributor.authorYıldız, İsmail
dc.contributor.authorAkın, Alper
dc.contributor.authorÜnal, Edip
dc.date.accessioned2024-04-24T19:11:17Z
dc.date.available2024-04-24T19:11:17Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Subclinical hypothyroidism (SH) is defined as an elevated serum thyroid-stimulating hormone (TSH) level with free thyroxine (fT4) level in the normal range. There are very few studies in the literature reporting on the effect of SH on lipid metabolism and carotid intima-media thickness (CIMT) in children.Methods: The study included 38 children diagnosed with SH and a control group comprising 38 healthy, euthyroid children. SH was diagnosed based on an elevated TSH level (4.2-20 mIU/L) and normal fT4 level measured in two morning fasting blood samples obtained at an interval of 2 to 6 weeks. Blood samples were collected by venipuncture in the morning after an overnight fast.Results: The patient group included 38 children (16 male, 22 female) with SH and the control group -38 healthy, euthyroid children (20 male, 18 female). Mean age was 8.1±3.6 years in the patient group and 8.9±2.4 years in the control group. In the patient group, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C), and LDL-C/HDL-C were higher compared to the control group (p=0.049, p=0.014, p=0.002, and 0.003, respectively). In the patient group, CIMT was also significantly higher compared to the control group (p=0.001). The patient group was further divided into two subgroups based on their serum TSH level: (I) patients with mildly elevated TSH (TSH=4.2±10 mIU/L) (n=33) and (II) patients with high TSH (TSH>=10 mIU/L) (n=5). However, no significant difference was found between the patients with mild and severe SH with regard to TC, LDL-C, HDL-C, triglyceride level and CIMT levels (p=0.635, p=0.424, p=0.310, p=0.342, and 0.610, respectively).Conclusion: Subclinical hypothyroidism leads to increased dyslipidemia (increased TC and LDL) and increased CIMT, which leads to increased risk of cardiovascular disease. Further studies are needed to substantiate these findings in children with SH.en_US
dc.identifier.endpage149en_US
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue2en_US
dc.identifier.startpage144en_US
dc.identifier.trdizinid227623
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/227623
dc.identifier.urihttps://hdl.handle.net/11468/27883
dc.identifier.volume9en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAssociation of Subclinical Hypothyroidism with Dyslipidemia and Increased Carotid Intima-Media Thickness in Childrenen_US
dc.titleAssociation of Subclinical Hypothyroidism with Dyslipidemia and Increased Carotid Intima-Media Thickness in Children
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu