Histopathologic effect of gonadal steroids and gender on goiter development in thyroid stimulated rabbits by TRH

Basit Öğe Kaydı
dc.contributor.authorAydin I.
dc.contributor.authorNergiz Y.
dc.contributor.authorKetani A.
dc.contributor.authorAslan I.
dc.date.accessioned2024-04-24T18:44:06Z
dc.date.available2024-04-24T18:44:06Z
dc.date.issued1995
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn order to assess the effect of gender and gonadal steroids on goiter development, thirty-two New Zealand albino rabbits were studied. The experimental protocol was based on histopathological changes observed in the thyroid gland following manipulation of gonadal hormone levels and stimulation by TRH. Gender differences for the structure end size of follicles following TRH administration remained significantly larger in females than in males (p < 0.001). In gonadectomied male and female groups, there appeared to be a quantitative difference in response to TRH. Follicular cell proliferation and papillary structures were prominent and the diameter of the follicles was significantly larger in males compared with females (P < 0.001). In gonadectomied rabbits treated with the opposite gonadal steroids, the appearance of papillary structures and basophilic character of the colloid on staining were also prominent in males. The results indicate that (i) estrogen promotes while androgen inhibits to some extent the stimulatory effects of TRH on thyroid follicular size; and (ii) although the data would support the effect of gender and sex steroids on goiter development, factors other than gonadal steroids are responsible for the higher incidence of goiter in females.en_US
dc.identifier.endpage143en_US
dc.identifier.issn1300-0144
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0029020589
dc.identifier.scopusqualityQ1
dc.identifier.startpage139en_US
dc.identifier.urihttps://hdl.handle.net/11468/24561
dc.identifier.volume24en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFollicular Diameteren_US
dc.subjectGonadal Steroidsen_US
dc.subjectGonadectomyen_US
dc.subjectThyrotropin Releasing Hormoneen_US
dc.titleHistopathologic effect of gonadal steroids and gender on goiter development in thyroid stimulated rabbits by TRHen_US
dc.titleHistopathologic effect of gonadal steroids and gender on goiter development in thyroid stimulated rabbits by TRH
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu