The VKORC1 gene homozygous polymorphism is markedly higher in Crimean Congo hemorrhagic fever patients

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dc.contributor.authorTurkdogan K.A.
dc.contributor.authorKarabacak M.
dc.contributor.authorAkpinar O.
dc.contributor.authorKarahan O.
dc.contributor.authorGüven F.M.K.
dc.contributor.authorEngin A.
dc.contributor.authorTurkdogan F.T.
dc.date.accessioned2024-04-24T18:45:44Z
dc.date.available2024-04-24T18:45:44Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn Crimean-Congo Hemorrhagic Fever (CCHF), the main target of the virus is endothelial cells, monocytes and hepatocytes. The virus in these cells leads to the development of capillary vessels dysfunction, which induces clinical and pathological changes during the disease. Increase in capillary permeability and coagulation dysfunction constitute a tendency to bleed. In the current study, we aimed to investigate the relationship between VKORC1 and bleeding tendency in CCHF. Forty-eight consecutive patients with a laboratory-confirmed diagnosis of CCHF were treated with blood products, and 37 healthy volunteers as the control group were prospectively enrolled into the study. The DNA was obtained from each sample using PCR amplification method, and VKORC1 1639 G>A gene polymorphisms were scanned in the DNA samples. In CCHF group of patients with bleeding VKORC1 gene were analyzed. Normal genotype was detected in 5 (22.7%) patients, homozygote mutation was detected in 2 (9.1%) patients and heterozygote mutation was detected in 15 (68.2%) patients, respectively. Furthermore, the G allele frequency was statistically higher in study group (51 [53%] vs. 27 [36%]) (p<0.005). It seems to be that VKORC1 gene A allele frequencies saliently higher in CCHF. This might be associated with increased bleeding risk in CCHF. Analyzing of VKORC1 gene polymorphisms could help in the risk stratification of patients with CCHF.en_US
dc.identifier.endpage420en_US
dc.identifier.issn0970-938X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84879290140
dc.identifier.scopusqualityN/A
dc.identifier.startpage415en_US
dc.identifier.urihttps://hdl.handle.net/11468/24844
dc.identifier.volume24en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofBiomedical Research (India)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBleedingen_US
dc.subjectCrimean-Congo Hemorrhagic Feveren_US
dc.subjectRisk Stratificationen_US
dc.subjectVkorc1 Geneen_US
dc.titleThe VKORC1 gene homozygous polymorphism is markedly higher in Crimean Congo hemorrhagic fever patientsen_US
dc.titleThe VKORC1 gene homozygous polymorphism is markedly higher in Crimean Congo hemorrhagic fever patients
dc.typeArticleen_US

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